Longevity in humans is considered a multifactorial phenotype to which various genetic and environmental factors are likely to contribute. About 30% of the variation in adult life span is attributable to genetic parameters. The main focus of the Junior Research Group on ‘Genetics of Human Longevity’ is to identify molecular signatures that lead to a long and healthy life.
Our current projects include whole genome, exome and transcriptome sequencing of centenarians, which should help us to obtain a broader perspective on the role of the genome in ageing and lifespan regulation.
Furthermore, we are continuously developing new approaches and sample recruitment strategies to unravel the genomic component of longevity including genetic, epigenetic, and transcriptomic determinants.
Special projects include: