Activated Fc alpha T cells in Crohn's disease are involved in regulation of IgA.

Authors:
A Raedler, S Schreiber, K H Schulz, S Peters, H Greten, H G Thiele
Year of publication:
1988
Volume:
237
Issue:
-
Issn:
0065-2598
Journal title abbreviated:
ADV EXP MED BIOL
Journal title long:
Advances in experimental medicine and biology
Impact factor:
1.953
Abstract: 
Activated peripheral T cells (APT) of patients with Crohn''s disease (CD) have been analysed for the expression of IgA-Fc receptors and for competence of IgA regulation. It was found that within the subset of APT an increased number of cells express binding sites for IgA (IgA-Fc), that was not found in other diseases with elevated numbers of APT. Moreover the number of IgA-Fc receptor expressing T cells was found to be increased in the inflamed mucosa too. Cocultures with autologous B cells revealed that isolated IgA-Fc receptor bearing T cells of patients with CD suppress IgA secretion. These data support the hypothesis that APT are involved in the immunopathogenesis of CD.