A common variant on chromosome 11q13 is associated with atopic dermatitis.

Authors:
Jorge Esparza-Gordillo, Stephan Weidinger, Regina Fölster-Holst, Anja Bauerfeind, Franz Ruschendorf, Giannino Patone, Klaus Rohde, Ingo Marenholz, Florian Schulz, Tamara Kerscher, Norbert Hubner, Ulrich Wahn, Stefan Schreiber, Andre Franke, Rainer Vogler, Simon Heath, Hansjörg Baurecht, Natalija Novak, Elke Rodriguez, Thomas Illig, Min-Ae Lee-Kirsch, Andrzej Ciechanowicz, Michael Kurek, Tereza Piskackova, Milan Macek, Young-Ae Lee, Andreas Ruether
Year of publication:
2009
Volume:
41
Issue:
5
Issn:
1061-4036
Journal title abbreviated:
NAT GENET
Journal title long:
Nature genetics
Impact factor:
31.616
Abstract: 
We conducted a genome-wide association study in 939 individuals with atopic dermatitis and 975 controls as well as 270 complete nuclear families with two affected siblings. SNPs consistently associated with atopic dermatitis in both discovery sets were then investigated in two additional independent replication sets totalling 2,637 cases and 3,957 controls. Highly significant association was found with allele A of rs7927894 on chromosome 11q13.5, located 38 kb downstream of C11orf30 (P(combined) = 7.6 x 10(-10)). Approximately 13% of individuals of European origin are homozygous for rs7927894[A], and their risk of developing atopic dermatitis is 1.47 times that of noncarriers.