Development of the Paris definition of early Crohn's disease for disease-modification trials: results of an international expert opinion process.

Authors:
Laurent Peyrin-Biroulet, Vincent Billioud, Geert D'Haens, Remo Panaccione, Brian Feagan, Julian Panés, Silvio Danese, Stefan Schreiber, Haruhiko Ogata, Toshifumi Hibi, Peter D R Higgins, Laurent Beaugerie, Yehuda Chowers, Edouard Louis, Flávio Steinwurz, Walter Reinisch, Paul Rutgeerts, Jean-Frédéric Colombel, Simon Travis, William J Sandborn
Year of publication:
2012
Volume:
107
Issue:
12
Issn:
0002-9270
Journal title abbreviated:
AM J GASTROENTEROL
Journal title long:
The American journal of gastroenterology : official publication of the National Gastroenterological Association
Impact factor:
10.383
Abstract: 
We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen experts on inflammatory bowel diseases held an international expert opinion meeting to discuss and agree on a definition for early CD to be used in disease-modification trials. The process included literature searches for the relevant basic-science and clinical evidence. A published preliminary definition of early CD was used as the basis for development of a proposed definition that was discussed at the expert opinion meeting. The participants then derived a final definition, based on best current knowledge, that it is hoped will be of practical use in disease-modification trials in CD.