GABA(A) receptor- and GABA transporter polymorphisms and risk for essential tremor.

Authors:
S Thier, G Kuhlenbäumer, D Lorenz, M Nothnagel, A Nebel, K Christensen, S Schreiber, G Deuschl, S Klebe
Year of publication:
2011
Volume:
18
Issue:
8
Issn:
1351-5101
Journal title abbreviated:
EUR J NEUROL
Journal title long:
European journal of neurology
Impact factor:
3.956
Abstract: 
In our samples, no evidence of association between GABA(A) R and GABA transporter genes with ET was detected. Further studies are necessary to clarify the role of these genes in ET.Nine nominally significant tagging SNPs (P values from 4.9×10(-2) to 5.2×10(-4) ) were found in the hypothesis generation stage. Five SNPs were followed up in a second verification stage but failed to reach significance. (P values from 0.30 to 0.77).A total of 503 ET cases and 818 controls were investigated for an association between polymorphisms in 15 GABA(A) R and four GABA transporter genes and ET.Clinical features and animal models of essential tremor (ET) suggest gamma-aminobutyric acid A receptor (GABA(A) R) subunits and GABA transporters as putative candidate genes.