Opportunities and challenges of whole-genome and -exome sequencing.

Authors:
Britt-Sabina Petersen, Broder Fredrich, Marc P Hoeppner, David Ellinghaus, Andre Franke
Year of publication:
2017
Volume:
18
Issue:
1
Issn:
1471-2156
Journal title abbreviated:
BMC GENET
Journal title long:
BMC genetics
Impact factor:
2.266
Abstract: 
Recent advances in the development of sequencing technologies provide researchers with unprecedented possibilities for genetic analyses. In this review, we will discuss the history of genetic studies and the progress driven by next-generation sequencing (NGS), using complex inflammatory bowel diseases as an example. We focus on the opportunities, but also challenges that researchers are facing when working with NGS data to unravel the genetic causes underlying diseases.