Polymorphisms of the IL12B and IL23R genes are associated with psoriasis.

Authors:
Rajan P Nair, Andreas Ruether, Philip E Stuart, Stefan Jenisch, Trilokraj Tejasvi, Ravi Hiremagalore, Stefan Schreiber, Dieter Kabelitz, Henry W Lim, John J Voorhees, Enno Christophers, James T Elder, Michael Weichenthal
Year of publication:
2008
Volume:
128
Issue:
7
Issn:
0022-202X
Journal title abbreviated:
J INVEST DERMATOL
Journal title long:
Journal of investigative dermatology
Impact factor:
6.915
Abstract: 
Psoriasis is a common inflammatory and hyperproliferative skin disease with a multifactorial genetic basis. A recent study reported that psoriasis was associated with the IL12B haplotype rs3212227 (3''-untranslated region)-rs6887695 (60 kb, 5'') and the IL23R haplotype rs7530511 (L310P)-rs11209026 (Q381R). We examined these four single-nucleotide polymorphisms (SNPs) for association with psoriasis in two groups of North American and German Caucasians: (1) 1,810 cases and 2,522 controls; and (2) 509 pedigrees. Both IL12B markers showed highly significant association with psoriasis in the case-control (rs3212227, odds ratio (OR)=1.62, P=1.7 x 10(-15); rs6887695, OR=1.49, P=2.7 x 10(-15)) and in the family-based analysis (rs3212227, P=2.2 x 10(-3); rs6887695, P=1.7 x 10(-3)). The IL23R SNPs also showed significant association in the cases and controls (rs7530511, OR=1.22, P=3.9 x 10(-3); rs11209026, OR=1.40, P=3.8 x 10(-4)). For both genes, common risk haplotypes were identified whose statistical significance approached (IL23R) or exceeded (IL12B) genome-wide criteria. We found no statistical evidence for interactions of these haplotypes with HLA-Cw6. Our results confirm associations between IL12B and IL23R and psoriasis in Caucasians, and provide a genetic basis for the clinical association between psoriasis and Crohn''s disease.