Role of the toll-like receptor 4 polymorphism Asp299Gly in longevity and myocardial infarction in German men.

Authors:
Almut Nebel, Friederike Flachsbart, Arne Schäfer, Michael Nothnagel, Susanna Nikolaus, Nour Eddine El Mokhtari, Stefan Schreiber
Year of publication:
2007
Volume:
128
Issue:
5-6
Issn:
0047-6374
Journal title abbreviated:
MECH AGEING DEV
Journal title long:
Mechanisms of ageing and development
Impact factor:
2.892
Abstract: 
In a previous study on Sicilian men, an association of the functional polymorphism Asp299Gly in the TLR4 gene was reported with longevity and a reduced risk of myocardial infarction (MI). Here, we sought to confirm the findings in our extensive collection of 273 long-lived men (95-107 years), 606 male early-onset MI patients and 594 appropriate controls from Germany. Despite sufficient statistical power to replicate the findings observed in the South Italians, our results rule out a noteworthy influence of the TLR4 polymorphism upon human longevity or MI in German men. Therefore, the previously described associations in Sicilians might reflect either population-specific or potentially false-positive results.