Successful application of belimumab in two patients with systemic lupus erythematosus experiencing a flare during tocilizumab treatment.

Authors:
M Jüptner, R Zeuner, S Schreiber, M Laudes, J O Schröder
Year of publication:
2014
Volume:
23
Issue:
4
Issn:
0961-2033
Journal title abbreviated:
Lupus
Journal title long:
Lupus
Abstract: 
This case report describes two female lupus patients who both received biological treatment with tocilizumab and with belimumab. The disease course was remarkably similar in both cases. Tocilizumab resulted in a transient improvement in pleurisy and arthritis but was then followed by a clinical flare accompanied by an increase in autoantibodies and a drop in complement levels. Alike, both patients experienced a rapid and sustained improvement after institution of belimumab. The clinical benefit obtained is currently stable under ongoing belimumab therapy.