Genetic Architecture of Longevity

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Facts & Details: 

We have recently conducted a genome-wide association study (GWAS) in ~760 long-lived individuals (94-110 years) and 1,085 younger controls (45-77 years) that revealed the APOE ε4 allele as the strongest factor influencing life and health span in humans. The same data set is currently being analyzed to evaluate the influence of copy number variations (CNVs) on longevity. Other GWAS using various microarrays are ongoing. In addition, we are sequencing whole genomes of centenarians. The projects are aimed at increasing the number of longevity-relevant variants and the obtained results may serve as a basis for functional studies. Collaboration partners are Michael Krawczak and Amke Caliebe from the Institute of Medical Informatics and Statistics at Kiel University.

Involved PhD students: Liljana Gentschew, Carolin Knecht and Nandini Badarinarayan.

Support: DFG Excellence Cluster "Inflammation at Interfaces", RESOLVE project FP7-HEALTH-F4-2008-202047

 

In connection with these studies the book by Andreas Labes and Stefan Schreiber "100 Jahre Leben",  has been published, please refer to the gallery below for some photos of Andreas Labes.

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