The host’s ability to discriminate “friend and foe” and establish a precise crosstalk with its associated microbiota is crucial for fitness and survival. Among the mediators of intestinal host-microbe interactions, NOD-like receptor (NLR) proteins take centre stage. They are present on the epithelial lining and innate immune cells that constantly monitor microbial activities at the intestinal barrier. Dysfunctional NLRs predispose towards intestinal inflammation as well as sensitize to extra-intestinal immune-mediated diseases and are linked to the alteration of microbial communities. The generation of microbicidal reactive oxygen species (ROS) contributes to mucosal defence, especially under pro-inflammatory conditions.
We are addressing questions in this field with a broad range of techniques and models, including systematic cellular studies and murine models of inflammation and infection.