Professor Konrad Aden receives funding from the Joachim Herz Foundation's Innovation Academy to find a metabolic biomarker for chronic inflammation.
Chronic inflammatory diseases are among the most rapidly increasing forms of illness worldwide in western industrialized nations. They can affect different organ systems, such as the intestines, skin, lungs or joints, and can lead to loss of organ function if left untreated. Members of the Cluster of Excellence "Precision Medicine in Chronic Inflammation" (PMI) are looking for innovative biomarkers, i.e. molecular, characteristic patterns that can be used to detect inflammatory processes at an early stage and thus shorten the time needed for diagnosis and treatment. There are currently no biomarkers that researchers can use to precisely determine systemic inflammation across all diseases using a blood sample - i.e. regardless of the organs in which the inflammation manifests itself, or they are only very imprecise in their diagnosis.
Professor Konrad Aden is researching the importance of amino acid metabolism in chronic inflammatory diseases. Previous research has already identified changes in amino acid metabolism in numerous chronic inflammatory diseases. Based on these findings, Aden has developed an innovative measurement method to visualize amino acid metabolism even more precisely in patients. He now wants to further develop this measurement method for broader use in clinical practice in order to make the changes in amino acid metabolism usable as a biomarker for chronic inflammation.
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