
Detailed stratified GWAS analysis for severe COVID-19 in four European populations
Authors
Frauke Degenhardt, David Ellinghaus, Simonas Juzenas, Jon Lerga-Jaso, Mareike Wendorff, Douglas Maya-Miles, Florian Uellendahl-Werth, Hesham ElAbd, Malte Rühlemann, Jatin Arora, Onur Özer, Ole Bernt Lenning, Ronny Myhre, May Sissel Vadla, Eike Wacker, Lars Wienbrandt, Aaron Blandino Ortiz, Adolfo de Salazar, Adolfo Garrido Chercoles, Adriana Palom, Agustín Ruiz, Alba-Estela Garcia-Fernandez, Albert Blanco-Grau, Alberto Mantovani, Alberto Zanella, Aleksander Rygh Holten, Alena Mayer, Alessandra Bandera, Alessandro Cherubini, Alessandro Protti, Alessio Aghemo, Alessio Gerussi, Alfredo Ramirez, Alice Braun, Almut Nebel, Ana Barreira, Ana Lleo, Ana Teles, Anders Benjamin Kildal, Andrea Biondi, Andrea Caballero-Garralda, Andrea Ganna, Andrea Gori, Andreas Glück, Andreas Lind, Anja Tanck, Anke Hinney, Anna Carreras Nolla, Anna Ludovica Fracanzani, Anna Peschuck, Annalisa Cavallero, Anne Ma Dyrhol-Riise, Antonella Ruello, Antonio Julià, Antonio Muscatello, Antonio Pesenti, Antonio Voza, Ariadna Rando-Segura, Aurora Solier, Axel Schmidt, Beatriz Cortes, Beatriz Mateos, Beatriz Nafria-Jimenez, Benedikt Schaefer, Björn Jensen, Carla Bellinghausen, Carlo Maj, Carlos Ferrando, Carmen de la Horra, Carmen Quereda, Carsten Skurk, Charlotte Thibeault, Chiara Scollo, Christian Herr, Christoph Spinner, Christoph Gassner, Christoph Lange, Cinzia Hu, Cinzia Paccapelo, Clara Lehmann, Claudio Angelini, Claudio Cappadona, Clinton Azuure, Cristiana Bianco, Cristina Cea, Cristina Sancho, Dag Arne Lihaug Hoff, Daniela Galimberti, Daniele Prati, David Haschka, David Jiménez, David Pestaña, David Toapanta, Eduardo Muñiz-Diaz, Elena Azzolini, Elena Sandoval, Eleonora Binatti, Elio Scarpini, Elisa Helbig, Elisabetta Casalone, Eloisa Urrechaga, Elvezia Maria Paraboschi, Emanuele Pontali, Enric Reverter, Enrique Calderón, Enrique Navas, Erik Solligård, Ernesto Contro, Eunate Arana-Arri, Fátima Aziz, Federico Garcia, Félix García Sánchez, Ferruccio Ceriotti, Filippo Martinelli-Boneschi, Flora Peyvandi, Florian Kurth, Francesco Blasi, Francesco Malvestiti, Francisco Medrano, Francisco Mesonero, Francisco Rodriguez-Frias, Frank Hanses, Fredrik Müller, Georg Hemmrich-Stanisak, Giacomo Bellani, Giacomo Grasselli, Gianni Pezzoli, Giorgio Costantino, Giovanni Albano, Giulia Cardamone, Giuseppe Bellelli, Giuseppe Citerio, Giuseppe Foti, Giuseppe Lamorte, Giuseppe Matullo, Guido Baselli, Hayato Kurihara, Holger Neb, Ilaria My, Ingo Kurth, Isabel Hernández, Isabell Pink, Itziar de Rojas, Iván Galván-Femenia, Jan Cato Holter, Jan Egil Afset, Jan Heyckendorf, Jan Kässens, Jan Kristian Damås, Jan Rybniker, Janine Altmüller, Javier Ampuero, Javier Martín, Jeanette Erdmann, Jesus Banales, Joan Ramon Badia, Joaquin Dopazo, Jochen Schneider, Jonas Bergan, Jordi Barretina, Jörn Walter, Jose Hernández Quero, Josune Goikoetxea, Juan Delgado, Juan Guerrero, Julia Fazaal, Julia Kraft, Julia Schröder, Kari Risnes, Karina Banasik, Karl Erik Müller, Karoline Gaede, Koldo Garcia-Etxebarria, Kristian Tonby, Lars Heggelund, Laura Izquierdo-Sanchez, Laura Rachele Bettini, Lauro Sumoy, Leif Erik Sander, Lena Lippert, Leonardo Terranova, Lindokuhle Nkambule, Lisa Knopp, Lise Tuset Gustad, Lucia Garbarino, Luigi Santoro, Luis Téllez, Luisa Roade, Mahnoosh Ostadreza, Maider Intxausti, Manolis Kogevinas, Mar Riveiro-Barciela, Marc Berger, Marco Schaefer, Mari EK Niemi, María Gutiérrez-Stampa, Maria Carrabba, Maria Figuera Basso, Maria Grazia Valsecchi, María Hernandez-Tejero, Maria JGT Vehreschild, Maria Manunta, Marialbert Acosta-Herrera, Mariella D’Angiò, Marina Baldini, Marina Cazzaniga, Marit Grimsrud, Markus Cornberg, Markus Nöthen, Marta Marquié, Massimo Castoldi, Mattia Cordioli, Maurizio Cecconi, Mauro D’Amato, Max Augustin, Melissa Tomasi, Mercè Boada, Michael Dreher, Michael Seilmaier, Michael Joannidis, Michael Wittig, Michela Mazzocco, Michele Ciccarelli, Miguel Rodríguez-Gandía, Monica Bocci
Year of publication
2021Journal
UKNVolume
-Issue
-Abstract
ABSTRACT
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of a well-characterized cohort of 3,260 COVID-19 patients with respiratory failure and 12,483 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen (HLA) region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a highly pleiotropic ∼0.9-Mb inversion polymorphism and characterized the potential effects of the inversion in detail. Our data, together with the 5 th release of summary statistics from the COVID-19 Host Genetics Initiative, also identified a new locus at 19q13.33, including NAPSA , a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.