Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19.

Authors

Florian Tran, Danielle M M Harris, Alena Scharmacher, Hanna Graßhoff, Kristina Sterner, Susanne Schinke, Nadja Käding, Jens Y Humrich, Otávio Cabral-Marques, Joana P Bernardes, Neha Mishra, Thomas Bahmer, Jeanette Franzenburg, Bimba F Hoyer, Andreas Glück, Martina Guggeis, Alexander Ossysek, Andre Küller, Derk Frank, Christoph Lange, Jan Rupp, Jan Heyckendorf, Karoline I Gaede, Howard Amital, Philip Rosenstiel, Yehuda Shoenfeld, Gilad Halpert, Avi Z Rosenberg, Kai Schulze-Forster, Harald Heidecke, Gabriela Riemekasten, Stefan Schreiber

Year of publication

2022

Journal

ERJ Open Res

Volume

Issue

ISSN

2312-0541

Impact factor

PubMed

https://pubmed.ncbi.nlm.nih.gov/36575710

Abstract

In patients with severe #COVID19, increased levels of autoantibodies against PAR1 were found. These might serve as allosteric agonists of PAR1 on endothelial cells and platelets, and thus might contribute to the pathogenesis of microthrombosis in COVID-19. https://bit.ly/3pqM9Vv.