Investigating the Crime Scene-Molecular Signatures in Inflammatory Bowel Disease.

Authors

Vibeke Andersen, Tue B Bennike, Corinna Bang, John D Rioux, Isabelle Hébert-Milette, Toshiro Sato, Axel K Hansen, Ole H Nielsen

Year of publication

2023

Journal

INT J MOL SCI

Volume

24

Issue

13

ISSN

1422-0067

Impact factor

6.208

Abstract

Inflammatory bowel diseases (IBD) are without cure and troublesome to manage because of the considerable diversity between patients and the lack of reliable biomarkers. Several studies have demonstrated that diet, gut microbiota, genetics and other patient factors are essential for disease occurrence and progression. Understanding the link between these factors is crucial for identifying molecular signatures that identify biomarkers to advance the management of IBD. Recent technological breakthroughs and data integration have fuelled the intensity of this research. This research demonstrates that the effect of diet depends on patient factors and gut microbial activity. It also identifies a range of potential biomarkers for IBD management, including mucosa-derived cytokines, gasdermins and neutrophil extracellular traps, all of which need further evaluation before clinical translation. This review provides an update on cutting-edge research in IBD that aims to improve disease management and patient quality of life.