Publications

Institut für Klinische Molekularbiologie der Christian-Albrechts-Universität zu Kiel

2022

PUFA-induced metabolic enteritis as a fuel for Crohn's disease.
PubMed (PMID: 35031299) | 2022 | Gastroenterology (New York, N.Y. 1943)
Staying strong during hibernation.
PubMed (PMID: 35084958) | 2022 | Science : a weekly journal devoted to the advancement of science / American Association for the Advancement of Science
Basic skin therapy effects on skin inflammation and microbiome composition in patients with atopic dermatitis after challenges with grass pollen.
PubMed (PMID: 35075709) | 2022 | Journal of European Academy of Dermatology and Venereology
Transethnic analysis of psoriasis susceptibility in South Asians and Europeans enhances fine-mapping in the MHC and genomewide.
PubMed (PMID: 34927100) | 2022 | HGG advances
Occasional paternal inheritance of the germline-restricted chromosome in songbirds.
PubMed (PMID: 35058355) | 2022 | Proceedings of the National Academy of Sciences of the United States of America
Signatures of TOP1 transcription-associated mutagenesis in cancer and germline.
PubMed (PMID: 35140396) | 2022 | Nature : a weekly illustrated journal of science
Cross-tissue transcriptome-wide association studies identify susceptibility genes shared between schizophrenia and inflammatory bowel disease.
PubMed (PMID: 35058554) | 2022 | Communications biology
Timing of antimicrobial prophylaxis for cesarean section is critical for gut microbiome development in term born infants.
PubMed (PMID: 35184691) | 2022 | Gut microbes
Linkage analysis identifies novel genetic modifiers of microbiome traits in families with inflammatory bowel disease.
PubMed (PMID: 35129060) | 2022 | Gut microbes
Detection of Cancer Mutations by Urine Liquid Biopsy as a Potential Tool in the Clinical Management of Bladder Cancer Patients.
PubMed (PMID: 35205727) | 2022 | Cancers
Local genetic variation of inflammatory bowel disease in Basque population and its effect in risk prediction.
PubMed (PMID: 35232999) | 2022 | Scientific Reports
A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 expression in human CD4<sup>+</sup> T cells and is defective in Crohn´s disease patients.
PubMed (PMID: 35169232) | 2022 | Mucosal immunology official journal of the Society for Mucosal Immunology
A novel unconventional T cell population enriched in Crohn's disease.
PubMed (PMID: 35264446) | 2022 | Gut : journal of the British Society of Gastroenterology
Detailed transcriptional landscape of peripheral blood points to increased neutrophil activation in treatment-naïve inflammatory bowel disease.
PubMed (PMID: 35022690) | 2022 | Journal of Crohn's & colitis : international journal devoted to inflammatory bowel diseases
Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity.
PubMed (PMID: 35264564) | 2022 | Nature communications
B-cell-depletion reverses dysbiosis of the microbiome in multiple sclerosis patients.
PubMed (PMID: 35260584) | 2022 | Scientific Reports
Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming.
PubMed (PMID: 35210413) | 2022 | Nature communications
TSPAN6 is a suppressor of Ras-driven cancer.
PubMed (PMID: 35184157) | 2022 | Oncogene
A Predictive Model for Progression of CKD to Kidney Failure Based on Routine Laboratory Tests.
PubMed (PMID: 34298143) | 2022 | American journal of kidney diseases : the official journal of the National Kidney Foundation
Educational Attainment Is Associated With Kidney and Cardiovascular Outcomes in the German CKD (GCKD) Cohort
PubMed (PMID: 10) | 2022 | Kidney international reports
A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies.
PubMed (PMID: 35348614) | 2022 | Brain : a journal of neurology
SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells.
PubMed (PMID: 35235832) | 2022 | Cell reports
miRNome Profiling and Functional Analysis Reveal Involvement of hsa-miR-1246 in Colon Adenoma-Carcinoma Transition by Targeting <i>AXIN2</i> and <i>CFTR</i>.
PubMed (PMID: 35216222) | 2022 | International journal of molecular sciences
Circulating microbiome in patients with portal hypertension.
PubMed (PMID: 35130114) | 2022 | Gut microbes
The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2.
PubMed (PMID: 35063125) | 2022 | Stem cell reports
Analysis of the fecal and oral microbiota in chronic recurrent multifocal osteomyelitis.
PubMed (PMID: 35193655) | 2022 | Arthritis research & therapy
Longitudinal monitoring of STAT3 phosphorylation and histologic outcome of tofacitinib therapy in patients with ulcerative colitis.
PubMed (PMID: 35484689) | 2022 | Alimentary pharmacology & therapeutics
Radiotherapy orchestrates natural killer cell dependent antitumor immune responses through CXCL8.
PubMed (PMID: 35319989) | 2022 | Science advances
A <i>dietary carbohydrate - gut Parasutterella - human fatty acid biosynthesis</i> metabolic axis in obesity and type 2 diabetes.
PubMed (PMID: 35435797) | 2022 | Gut microbes
Hyper/neuroinflammation in COVID-19 and suicide etiopathogenesis: Hypothesis for a nefarious collision?
PubMed (PMID: 35289272) | 2022 | Neuroscience & biobehavioral reviews : official journal of the International Behavioral Neuroscience Society
Single-cell atlas of the aging mouse colon.
PubMed (PMID: 35479413) | 2022 | iScience
How genetic risk contributes to autoimmune liver disease.
PubMed (PMID: 35650446) | 2022 | Seminars in immunopathology
Novel genes and sex differences in COVID-19 severity.
PubMed (PMID: 35708486) | 2022 | Human molecular genetics
Heart Failure Severity Closely Correlates with Intestinal Dysbiosis and Subsequent Metabolomic Alterations.
PubMed (PMID: 35453559) | 2022 | Biomedicines
NMR Metabolomics Reveal Urine Markers of Microbiome Diversity and Identify Benzoate Metabolism as a Mediator between High Microbial Alpha Diversity and Metabolic Health.
PubMed (PMID: 35448495) | 2022 | Metabolites
Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies.
PubMed (PMID: 35684151) | 2022 | Nutrients
Efficacy, T cell activation and antibody responses in accelerated Plasmodium falciparum sporozoite chemoprophylaxis vaccine regimens.
PubMed (PMID: 35641527) | 2022 | NPJ vaccines
<i>Mycobacterium tuberculosis</i>-specific CD4 T-cell scoring discriminates tuberculosis infection from disease.
PubMed (PMID: 35618277) | 2022 | The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology
High-throughput method for the hybridisation-based targeted enrichment of long genomic fragments for PacBio third-generation sequencing.
PubMed (PMID: 35855323) | 2022 | NAR Genomics and Bioinformatics
The intracellular proteome of the gut bacterium Bacteroides thetaiotaomicron is widely unaffected by a switch from glucose to sucrose as main carbohydrate source.
PubMed (PMID: 35906788) | 2022 | Proteomics
Mitochondrial Function and Microbial Metabolites as Central Regulators of Intestinal Immune Responses and Cancer.
PubMed (PMID: 35847099) | 2022 | Frontiers in Microbiology
Elucidation of the genetic causes of bicuspid aortic valve disease.
PubMed (PMID: 35727948) | 2022 | Cardiovascular research
Detailed stratified GWAS analysis for severe COVID-19 in four European populations.
PubMed (PMID: 35848942) | 2022 | Human molecular genetics
Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy.
PubMed (PMID: 35997131) | 2022 | Movement disorders : official journal of the Movement Disorder Society
GWAS meta-analysis of 16 790 patients with Barrett's oesophagus and oesophageal adenocarcinoma identifies 16 novel genetic risk loci and provides insights into disease aetiology beyond the single marker level.
PubMed (PMID: 35882562) | 2022 | Gut : journal of the British Society of Gastroenterology
Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility.
PubMed (PMID: 36038634) | 2022 | Nature genetics
Biodiversity, environmental drivers, and sustainability of the global deep-sea sponge microbiome.
PubMed (PMID: 36056000) | 2022 | Nature communications
Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies.
PubMed (PMID: 35716955) | 2022 | Kidney international
Bovine milk microbiota: Evaluation of different DNA extraction protocols for challenging samples.
PubMed (PMID: 35478279) | 2022 | MicrobiologyOpen
Performance of the Use of Genetic Information to Assess the Risk of Colorectal Cancer in the Basque Population.
PubMed (PMID: 36077729) | 2022 | Cancers
Resolving SARS-CoV-2 CD4<sup>+</sup> T cell specificity via reverse epitope discovery.
PubMed (PMID: 35841887) | 2022 | Cell reports. Medicine
The pre-exposure SARS-CoV-2-specific T cell repertoire determines the quality of the immune response to vaccination.
PubMed (PMID: 35985324) | 2022 | Immunity (Cambridge, Mass.)
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids.
PubMed (PMID: 35931049) | 2022 | American journal of human genetics
Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation.
PubMed (PMID: 35931020) | 2022 | Cell
Distinct Longitudinal Changes in Immunoglobulin G N-Glycosylation Associate with Therapy Response in Chronic Inflammatory Diseases.
PubMed (PMID: 35955616) | 2022 | International journal of molecular sciences
Key features of the genetic architecture and evolution of host-microbe interactions revealed by high-resolution genetic mapping of the mucosa-associated gut microbiome in hybrid mice.
PubMed (PMID: 35866635) | 2022 | eLife
Genetic variation in <i>TERT</i> modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study.
PubMed (PMID: 35788059) | 2022 | Gut : journal of the British Society of Gastroenterology
Dysbiosis in the Gut Microbiota in Patients with Inflammatory Bowel Disease during Remission.
PubMed (PMID: 35532243) | 2022 | Microbiology spectrum
Long-Term Dietary Effects on Human Gut Microbiota Composition Employing Shotgun Metagenomics Data Analysis.
PubMed (PMID: 35760036) | 2022 | Molecular nutrition & food research
Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in a murine model of PSC.
PubMed (PMID: 35705368) | 2022 | Gut : journal of the British Society of Gastroenterology
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.
PubMed (PMID: 35697829) | 2022 | Communications biology
UBTF::ATXN7L3 gene fusion defines novel B cell precursor ALL subtype with CDX2 expression and need for intensified treatment.
PubMed (PMID: 35397658) | 2022 | Leukemia
Utilisation of supplementary prenatal screening and diagnostics in Germany: cross-sectional study using data from the KUNO Kids Health Study.
PubMed (PMID: 35610584) | 2022 | BMC pregnancy and childbirth
Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins.
PubMed (PMID: 36074822) | 2022 | Science : a weekly journal devoted to the advancement of science / American Association for the Advancement of Science
The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection.
PubMed (PMID: 36074821) | 2022 | Science : a weekly journal devoted to the advancement of science / American Association for the Advancement of Science
EagleImp: Fast and Accurate Genome-wide Phasing and Imputation in a Single Tool.
PubMed (PMID: 36130053) | 2022 | Bioinformatics
Early Onset of TNFα-Driven Arthritis, Auto-inflammation, and Progressive Loss of Vision in a Patient with ALPK1 Mutation.
PubMed (PMID: 35235128) | 2022 | Journal of clinical immunology
Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota.
PubMed (PMID: 36261456) | 2022 | Nature communications
MAGScoT - a fast, lightweight, and accurate bin-refinement tool.
PubMed (PMID: 36264141) | 2022 | Bioinformatics
DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon.
PubMed (PMID: 36271073) | 2022 | Nature communications
Genomic characterization of the world's longest selection experiment in mouse reveals the complexity of polygenic traits.
PubMed (PMID: 35189878) | 2022 | BMC biology