A 5,000-year-old hunter-gatherer already plagued by Yersinia pestis.

Authors:
Julian Susat, Harald Lübke, Alexander Immel, Ute Brinker, Aija Macāne, John Meadows, Britta Steer, Andreas Tholey, Ilga Zagorska, Guntis Gerhards, Ulrich Schmölcke, Mārcis Kalniņš, Andre Franke, Elīna Pētersone-Gordina, Barbara Teßman, Mari Tõrv, Stefan Schreiber, Christian Andree, Valdis Bērziņš, Almut Nebel, Ben Krause-Kyora
Year of publication:
2021
Volume:
35
Issue:
13
Issn:
2211-1247
Journal title abbreviated:
CELL REP
Journal title long:
Cell reports
Impact factor:
9.423
Abstract:
A 5,000-year-old Yersinia pestis genome (RV 2039) is reconstructed from a hunter-fisher-gatherer (5300-5050 cal BP) buried at Riņņukalns, Latvia. RV 2039 is the first in a series of ancient strains that evolved shortly after the split of Y. pestis from its antecessor Y. pseudotuberculosis ∼7,000 years ago. The genomic and phylogenetic characteristics of RV 2039 are consistent with the hypothesis that this very early Y. pestis form was most likely less transmissible and maybe even less virulent than later strains. Our data do not support the scenario of a prehistoric pneumonic plague pandemic, as suggested previously for the Neolithic decline. The geographical and temporal distribution of the few prehistoric Y. pestis cases reported so far is more in agreement with single zoonotic events.