AKT1 fails to replicate as a longevity-associated gene in Danish and German nonagenarians and centenarians.

Authors:
Marianne Nygaard, Mette Soerensen, Friederike Flachsbart, Jonas Mengel-From, Qihua Tan, Stefan Schreiber, Almut Nebel, Kaare Christensen, Lene Christiansen
Year of publication:
2013
Volume:
21
Issue:
5
Issn:
1018-4813
Journal title abbreviated:
EUR J HUM GENET
Journal title long:
European journal of human genetics
Impact factor:
4.580
Abstract:
In addition to APOE and FOXO3, AKT1 has recently been suggested as a third consistent longevity gene, with variants in AKT1 found to be associated with human lifespan in two previous studies. Here, we evaluated AKT1 as a longevity-associated gene across populations by attempting to replicate the previously identified variant rs3803304 as well as by analyzing six additional AKT1 single-nucleotide polymorphisms, thus capturing more of the common variation in the gene. The study population was 2996 long-lived individuals (nonagenarians and centenarians) and 1840 younger controls of Danish and German ancestry. None of the seven SNPs tested were significantly associated with longevity in either a case-control or a longitudinal setting, although a supportive nominal indication of a disadvantageous effect of rs3803304 was found in a restricted group of Danish centenarian men. Overall, our results do not support AKT1 as a universal longevity-associated gene.