Association to the Glypican-5 gene in multiple sclerosis.

Authors:
Aslaug R Lorentzen, Espen Melum, Eva Ellinghaus, Cathrine Smestad, Inger-Lise Mero, Jan H Aarseth, Kjell-Morten Myhr, Elisabeth G Celius, Benedicte A Lie, Tom H Karlsen, Andre Franke, Hanne F Harbo
Year of publication:
2010
Volume:
226
Issue:
1-2
Issn:
0165-5728
Journal title abbreviated:
J NEUROIMMUNOL
Journal title long:
Journal of neuroimmunology : official bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology
Impact factor:
2.536
Abstract:
Multiple sclerosis (MS) is an inflammatory, demyelinating disease affecting the central nervous system. MS-associated variants have been reported at both HLA and non-HLA loci, the latter including chromosome 13q31-32 and the Glypican-5 and Glypican-6 genes. In order to further explore the 13q31-32 region in MS, we genotyped 33 SNPs in 1355 Norwegian MS patients and 1446 Norwegian controls. An intronic SNP in the Glypican-5 gene (rs9523787) showed association with MS (p(corr)=0.006). Thus, this study supports that MS susceptibility at 13q31-32 may localize to the Glypican-5 gene, which should lead to further fine-mapping, replication and functional studies of this gene.