A candidate gene approach of the calcineurin pathway to identify variants associated with clinical outcomes in renal transplantation.

Authors:
Lucie Pouché, Matthias Koitka, Jana Stojanova, Jean-Baptiste Woillard, Caroline Monchaud, Claire Villeneuve, Marie Essig, Julie Abraham, Yannick Le Meur, Jean-Phillippe Rerolle, Nassim Kamar, Lionel Rostaing, Pierre Merville, Peggy Gandia, Stephane Bouchet, Britt-Sabina Petersen, Pierre Marquet, Nicolas Picard
Year of publication:
2016
Volume:
-
Issue:
-
Issn:
1462-2416
Journal title abbreviated:
PHARMACOGENOMICS
Journal title long:
Pharmacogenomics
Impact factor:
2.339
Abstract:
To investigate the potential influence of variants in genes involved in the calcineurin pathway on the efficacy and toxicity of calcineurin inhibitors in renal transplantation.Twenty-three polymorphisms in thirteen genes were tested in 381 renal transplant recipients receiving ciclosporin (n = 221) or tacrolimus (n = 160) and mycophenolate mofetil. Data were collected prospectively over the first year post-transplantation.Multivariate survival analyses revealed no genetic associations with biopsy proven acute graft rejection and serious infections. Donor-recipient Cytomegalovirus mismatch was the only variable associated with serious infection.This large exploratory study casts doubts on the potential interest of genetic biomarkers related to CNI pharmacodynamics but associations with other phenotypes in transplantation deserve further studies.