Dynamics of the mucosa-associated flora in ulcerative colitis patients during remission and clinical relapse.

Authors:
Stephan J Ott, Sophie Plamondon, Ailsa Hart, Alexander Begun, Ateequr Rehman, Michael A Kamm, Stefan Schreiber
Year of publication:
2008
Volume:
46
Issue:
10
Issn:
0095-1137
Journal title abbreviated:
J CLIN MICROBIOL
Journal title long:
Journal of clinical microbiology
Impact factor:
3.631
Abstract:
The colonic mucosa-associated flora (MAF) in patients with active ulcerative colitis (UC) (n = 13) was investigated by examining 16S rRNA gene signatures during remission and relapse against levels for controls (n = 5). Baseline reduction, temporal instability, and decrease of bacterial richness toward relapse were observed for UC patients, whereas the MAF for controls was stable over time.