Functions of the Microbiota for the Physiology of Animal Metaorganisms.

Authors:
Daniela Esser, Janina Lange, Georgios Marinos, Michael Sieber, Lena Best, Daniela Prasse, Jay Bathia, Malte C Rühlemann, Kathrin Boersch, Cornelia Jaspers, Felix Sommer
Year of publication:
2018
Volume:
-
Issue:
-
Issn:
1662-811X
Journal title abbreviated:
J INNATE IMMUN
Journal title long:
Journal of innate immunity
Impact factor:
4.085
Abstract:
Animals are usually regarded as independent entities within their respective environments. However, within an organism, eukaryotes and prokaryotes interact dynamically to form the so-called metaorganism or holobiont, where each partner fulfils its versatile and crucial role. This review focuses on the interplay between microorganisms and multicellular eukaryotes in the context of host physiology, in particular aging and mucus-associated crosstalk. In addition to the interactions between bacteria and the host, we highlight the importance of viruses and nonmodel organisms. Moreover, we discuss current culturing and computational methodologies that allow a deeper understanding of underlying mechanisms controlling the physiology of metaorganisms.