Genetic association of nonsynonymous variants of the IL23R with familial and sporadic inflammatory bowel disease in women.

Authors:
Zhenwu Lin, Lisa Poritz, Andre Franke, Tong-Yi Li, Andreas Ruether, Kathryn A Byrnes, Yunhua Wang, Anthony W Gebhard, Colin MacNeill, Neal J Thomas, Stefan Schreiber, Walter A Koltun
Year of publication:
2010
Volume:
55
Issue:
3
Issn:
0163-2116
Journal title abbreviated:
DIGEST DIS SCI
Journal title long:
Digestive diseases and sciences
Impact factor:
2.819
Abstract:
To replicate the association of IL23R R381Q (rs11209026) with inflammatory bowel disease (IBD), examine the effect of the two nonsynonymous variations, Q3H and L310P, on IBD, and to study gender distribution of these variants in IBD patients.We replicated the association of IL23R R381Q with CD but not UC, and we observed an association of L310P with UC, but not CD, in a central Pennsylvania population. Further analysis of the distribution of IL23R variants revealed that these effects were largely female-specific. The results suggest that IL23R R381Q confers protection against CD and that L310P confers protection against UC in females.IL23R R381Q was associated with Crohn''s disease (CD) (P = 0.010), but not with ulcerative colitis (UC); L310P was associated with UC (P = 0.004), but not with CD; no association was observed for Q3H with CD or UC. A female-specific association of R381Q with CD (P = 0.041), and of L310P with UC (P = 0.008) was observed.