Genetics of Crohn disease, an archetypal inflammatory barrier disease.

Authors:
Stefan Schreiber, Philip Rosenstiel, Mario Albrecht, Jochen Hampe, Michael Krawczak
Year of publication:
2005
Volume:
6
Issue:
5
Issn:
1471-0056
Journal title abbreviated:
Nat. Rev. Genet.
Journal title long:
Nature reviews. Genetics
Impact factor:
39.794
Abstract:
Chronic inflammatory disorders such as Crohn disease, atopic eczema, asthma and psoriasis are triggered by hitherto unknown environmental factors that function on the background of some polygenic susceptibility. Recent technological advances have allowed us to unravel the genetic aetiology of these and other complex diseases. Using Crohn disease as an example, we show how the discovery of susceptibility genes furthers our understanding of the underlying disease mechanisms and how it will, ultimately, give rise to new therapeutic developments. The long-term goal of such endeavours is to develop targeted prophylactic strategies. These will probably target the molecular interaction on the mucosal surface between the products of the genome and the microbial metagenome of a patient.