Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).

Authors:
Andre Franke, Tobias Balschun, Christian Sina, David Ellinghaus, Robert Häsler, Gabriele Mayr, Mario Albrecht, Michael Wittig, Eva Buchert, Susanna Nikolaus, Christian Gieger, H Erich Wichmann, Jurgita Sventoraityte, Limas Kupcinskas, Clive M Onnie, Maria Gazouli, Nicholas P Anagnou, David Strachan, Wendy L McArdle, Christopher G Mathew, Paul Rutgeerts, Séverine Vermeire, Morten H Vatn, - -, Michael Krawczak, Philip Rosenstiel, Tom H Karlsen, Stefan Schreiber
Year of publication:
2010
Volume:
42
Issue:
4
Issn:
1061-4036
Journal title abbreviated:
NAT GENET
Journal title long:
Nature genetics
Impact factor:
27.125
Abstract:
We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P(rs7809799) = 8.81 x 10(-11) and P(rs5771069) = 4.21 x 10(-8), respectively).