Host susceptibility to tuberculosis: CARD15 polymorphisms in a South African population.

Authors:
Marlo Möller, Almut Nebel, Ruta Kwiatkowski, Paul D van Helden, Eileen G Hoal, Stefan Schreiber
Year of publication:
2007
Volume:
21
Issue:
2
Issn:
0890-8508
Journal title abbreviated:
MOL CELL PROBE
Journal title long:
Molecular and cellular probes
Impact factor:
1.565
Abstract:
Tuberculosis (TB) is one of the leading causes of death worldwide. The nucleotide-binding oligomerisation domain 2 protein (NOD2) has recently been recognised as a non-redundant recognition mechanism of Mycobacterium tuberculosis. The caspase recruitment domain-containing protein 15 gene (CARD15), which encodes the NOD2 protein, is a susceptibility gene for Crohn''s disease (CD), a granulomatous, chronic inflammatory disorder. CARD15 was therefore investigated as a candidate gene in TB. We genotyped the R702W, G908R and 1007fs variants, previously associated with CD, in TB cases and controls from the admixed South African Coloured population. No statistically significant differences between cases and controls were observed for these variants. We determined that the CD-associated mutations occur at very low frequencies in this population. Our results indicate that CARD15 is not a major susceptibility gene for TB in the South African Coloureds.