LINGO1 polymorphisms are associated with essential tremor in Europeans.

Authors:
Sandra Thier, Delia Lorenz, Michael Nothnagel, Giovanni Stevanin, Alexandra Dürr, Almut Nebel, Stefan Schreiber, Gregor Kuhlenbäumer, Günther Deuschl, Stephan Klebe
Year of publication:
2010
Volume:
25
Issue:
6
Issn:
0885-3185
Journal title abbreviated:
MOVEMENT DISORD
Journal title long:
Movement disorders : official journal of the Movement Disorder Society
Impact factor:
6.010
Abstract:
Essential tremor (ET) is one of the most common movement disorders. Former association studies focussing on candidate genes in ET found a number of risk variants but most of them were not replicated. Recently, a genome-wide association study revealed two intronic sequence variants in the LINGO1 gene associated with ET. Here, we have confirmed association between sequence variants in the LINGO1 gene and the ET phenotype in independent German and French ET samples. The odds ratios for the identified intronic markers rs8030859 (P = 1.0x10(-4)), rs9652490 (P = 9.1x10(-4)), and rs11856808 (P = 3.6x10(-2)) were 1.72 (CI 1.31-2.26), 1.61 (CI 1.21-2.14), and 1.30 (CI 1.02-1.66), respectively, in our German sample. LINGO1 is an interesting candidate gene because it plays a key role in central nervous system biology, is selectively expressed in the nervous system, and is an inhibitor of oligodendrocyte differentiation and neuronal myelination. Our study gives further evidence that LINGO1 acts as a susceptibility gene for ET.