Low-Frequency Blood Group Antigens in Switzerland.

Authors:
Christoph Gassner, Frauke Degenhardt, Stefan Meyer, Caren Vollmert, Nadine Trost, Kathrin Neuenschwander, Yvonne Merki, Claudia Portmann, Sonja Sigurdardottir, Antigoni Zorbas, Charlotte Engström, Jochen Gottschalk, Soraya Amar El Dusouqui, Sophie Waldvogel-Abramovski, Emmanuel Rigal, Jean-Daniel Tissot, Caroline Tinguely, Simon M Mauvais, Amira Sarraj, Daniel Bessero, Michele Stalder, Laura Infanti, Andreas Buser, Jörg Sigle, Tina Weingand, Damiano Castelli, Monica C Braisch, Jutta Thierbach, Sonja Heer, Thomas Schulzki, Michael Krawczak, Andre Franke, Beat M Frey
Year of publication:
2018
Volume:
45
Issue:
4
Issn:
1660-3796
Journal title abbreviated:
TRANSFUS MED HEMOTH
Journal title long:
Transfusion medicine and hemotherapy
Impact factor:
1.937
Abstract:
Background:High-frequency blood group antigens (HFA) are present in >90% of the human population, according to some reports even in >99% of individuals. Therefore, patients lacking HFA may become challenging for transfusion support because compatible blood is hardly found, and if the patient carries alloantibodies, the cross-match will be positive with virtual every red cell unit tested. Methods:In this study, we applied high-throughput blood group SNP genotyping on >37,000 Swiss blood donors, intending to identify homozygous carriers of low-frequency blood group antigens (LFA). Results:326 such individuals were identified and made available to transfusion specialists for future support of patients in need of rare blood products. Conclusion:Thorough comparison of minor allele frequencies using population genetics revealed heterogeneity of allele distributions among Swiss blood donors which may be explained by the topographical and cultural peculiarities of Switzerland. Moreover, geographically localized donor subpopulations are described which contain above-average numbers of individuals carrying rare blood group genotypes.