Molecular signatures of the three stem cell lineages in hydra and the emergence of stem cell function at the base of multicellularity.

Authors:
Georg Hemmrich, Konstantin Khalturin, Anna-Marei Boehm, Malte Puchert, Friederike Anton-Erxleben, Jörg Wittlieb, Ulrich C Klostermeier, Philip Rosenstiel, Hans-Heinrich Oberg, Tomislav Domazet-Loso, Toshimi Sugimoto, Hitoshi Niwa, Thomas C G Bosch
Year of publication:
2012
Volume:
29
Issue:
11
Issn:
0737-4038
Journal title abbreviated:
MOL BIOL EVOL
Journal title long:
Molecular biology and evolution
Impact factor:
13.649
Abstract:
How distinct stem cell populations originate and whether there is a clear stem cell "genetic signature" remain poorly understood. Understanding the evolution of stem cells requires molecular profiling of stem cells in an animal at a basal phylogenetic position. In this study, using transgenic Hydra polyps, we reveal for each of the three stem cell populations a specific signature set of transcriptions factors and of genes playing key roles in cell type-specific function and interlineage communication. Our data show that principal functions of stem cell genes, such as maintenance of stemness and control of stem cell self-renewal and differentiation, arose very early in metazoan evolution. They are corroborating the view that stem cell types shared common, multifunctional ancestors, which achieved complexity through a stepwise segregation of function in daughter cells.