New IL-15 receptor-α splicing variants identified in intestinal epithelial Caco-2 cells.

Authors:
Celia Escudero-Hernández, Beatriz Martínez-Abad, Violeta Ruipérez, José A Garrote, Eduardo Arranz
Year of publication:
2017
Volume:
23
Issue:
1
Issn:
1753-4259
Journal title abbreviated:
INNATE IMMUN
Journal title long:
Innate immunity (London, England)
Impact factor:
2.298
Abstract:
IL-15 is a pleiotropic cytokine related to IL-2 which acts at a broader level than its counterpart. It is presented through its specific high-affinity receptor, IL-15Rα. Both cytokine and receptor are tightly regulated at multiple levels and are widely distributed. Thus, deregulation of their expression leads to an inflammatory immune response. Variants of splicing of IL-15Rα have been described in immune and barrier cells; however, their presence has not been focused on intestinal epithelial cells. In this study, we describe five new alternative variants of splicing of IL-15Rα in Caco-2 cells. Four of them were expressed into proteins inside Caco-2 cells, but these were unable to bind IL-15 or to follow the secretory pathway. However, the expression of mRNA itself might be relevant to diseases such as celiac disease, inflammatory bowel disease or colorectal cancer.