Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis.

Authors:
Andre Franke, Tobias Balschun, Tom H Karlsen, Jürgen Hedderich, Sandra May, Tim Lu, Dörthe Schuldt, Susanna Nikolaus, Philip Rosenstiel, Michael Krawczak, Stefan Schreiber
Year of publication:
2008
Volume:
40
Issue:
6
Issn:
1061-4036
Journal title abbreviated:
NAT GENET
Journal title long:
Nature genetics
Impact factor:
31.616
Abstract:
Following up on recent genome-wide association studies (GWAS) of Crohn''s disease, we investigated 50 previously reported susceptibility loci in a German sample of individuals with Crohn''s disease (n = 1,850) or ulcerative colitis (n = 1,103) and healthy controls (n = 1,817). Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection.