Infection Oncology

Contact

Group Leader

Administration

Anna Gegautzke
Facts & Details: 

The Role of Bacterial Infections in Human Carcinogenesis and other Remote Diseases


The human mucosa is the major crossing point for molecular interaction between our body and the environment. This is where most pathogens initiate their infections and where our defense system is challenged to rapidly counteract any approaching assaults. Repeated or persistent onslaughts of this kind, however, tend to cause permanent damage to our epithelium, and, not surprisingly, the mucosal epithelium is the site most prone to carcinogenesis, a consequence of enhanced mutagenesis, inflammation and cell proliferation. Several clear links have been noted between chronic bacterial infections and carcinogenesis; however, the underlying mechanisms of this relationship are still sparsely understood.

Moreover, chronic colonization of the human mucosal surfaces by pathogens or changes in the composition of our microbiota may provoke harmful signals, misleading our immune and neuronal systems. In the long run, one of the consequences may be neuroinflammation. Exploring these mechanisms promises to pave the way towards better prevention and treatment of devastating diseases.

Our research applies sophisticated approaches to illuminate the relationship between infection and remote diseases, including cancer or neurodegeneration:

Carcinogenic microbes __Helicobacter pylori (2)

 

Carcinogenic microbes


The gastric pathogen Helicobacter pylori is the paradigm of a cancer-inducing bacterium. Understanding the mechanisms behind this link will help define the principles of an infection-cancer connection. We are also investigating the mechanisms behind the suggested carcinogenic effects of several other bacterial species, including Chlamydia trachomatis, Colibactin producing Escherichia coli.

 
OVK23 from Thieck OTO14 MB201 confocal 07-05FTOVK73

 

       

Origin of cancer-initiating cells


While our understanding of cancer evolution and progression has greatly improved in recent years, the initiation of carcinogenesis is a much more elusive phenomenon. We are developing sophisticated genetic lineage-tracing tools to help illuminate the very earliest events in cancer initiation as a result of infection and the various stages of carcinogenesis.

 

Signatures of infection in the cancer genome


Unlike oncogenic viruses, bacteria do not leave genetic material in the genome of
host cells. It is therefore much more difficult to prove that some bacterial infections
can promote the emergence of cancer – often many years later. Nonetheless,
epidemiology suggests that these bacteria-cancer relationships exist. Identifying
genetic signatures that bacterial pathogens might leave behind in human cells might
therefore provide genuine proof of the causality between infections and cancer
emergence and facilitate our understanding of the molecular mechanisms responsible.
We are using the most advanced tools of molecular biology, genetics and genomics in
order to identify such signatures.

 

Human organoids GAT18A-Wnt-Rspo_Ki67_2

 

Human organoids and mucosoids and other sophisticated research tools


The use of human primary cell culture models is crucial for authentic investigations of cancer emergence. We have pioneered the use of innovative organoid and mucosoid models, providing invaluable tools for modeling infection processes and their consequences in normal healthy cells.
Breakthrough technologies, such as RNA interference and CRISPR/Cas9, are extensively used in our work to decipher beneficial and potentially deleterious gene functions and genetic defects.

 

The unexpected link between our guts and the brain


Increasing evidence suggests an important link between the gastrointestinal tract and
the brain. Studies have revealed direct contact of the mucosal epithelium with nerve cells
that directly lead to the brain. Specifically, the Nervus Vagus, part of the parasympathetic
nerve system, transmits signals directly from the brain to the gut mucosa and the other
way around, from the guts and the stomach to the brain. The information delivered
appears to be manifold and includes inflammatory stimuli that may drive
neuroinflammation and thereby the development of related diseases, such as
Alzheimer’s and Parkinson’s. Numerous observations support this link; however,
the mechanisms behind it are enigmatic and, thus, are the subject of our studies.
The aim is to acquire a basic understanding and elucidate effective
treatment and prevention options.      

 

 

ERC Group Leader:
Prof. Dr. Thomas F. Meyer
(Senior Professor, Medical Faculty CAU, Kiel;
Director Emeritus, Max Planck Institute for Infection Biology, Berlin;
Honorary Professor, Charité University Medicine Berlin;
Honorary Professor, Humboldt University Berlin
)
Management:
Anna Gegautzke (part time)
 
Students:
Peng Huo (medical science)
Álvaro Quevedo Olmos (bioinformatics)
Lucas Riedel (natural sciences)
Zeyang Sun (medical science)
Shihan Wang (natural sciences)
Xiaochen Zhang (medical science)
Scientists:
Dr. Saskia Erttmann (part time, Jun. Prof. Umea Sweden)
Dr. Marzieh Ehsani, Ph. D.
 
Technicians:
Nina-Kristin Staack
Associated:
Dr. Maria del Mar Reines (Technical University Berlin)
Dr. Lennart Pfannkuch (Charité Berlin)
Dr. Mariel Garcia Chagollan (university of Guadalajara, Mexico)
Dr. David Holthaus (Gynecology UKSH Campus Kiel)
 

Main Publications

show all publications