The Junior Research Group “Epitranscriptome Regulation in Host-Microbe-Interactions” was established in 2020.
We are interested in studying is the influence of bacteria- pathogens as well as the microbiota- on host physiology.
Commensal bacteria, in particular the gut microbiota, have profound effects on host physiology, including host metabolism, intestinal morphology, or the development of the immune system. Dysbiosis of the microbiota, but also select bacterial species, can influence the development of multiple diseases, such as inflammatory bowel disease, colorectal cancer, diabetes or metabolic syndrome. We are interested in mechanisms by which commensal bacteria and their metabolites influence disease development by modulating gene expression in host tissues.
Our attention here is focused on epitranscriptomic modifications, i.e. posttranscriptional mRNA modifications that have been shown to be important regulators of mRNA fate. We are studying how these modifications are influenced by commensal, but also pathogenic, bacteria and examine the physiological relevance of mRNA modifications in the context of select inflammatory and metabolic diseases applying state-of-the art cell biology, imaging, RNA-sequencing and single cell sequencing approaches to study cellular, organoid and gnotobiotic and transgenic mouse models.
The group is always interested in motivated students to conduct their bachelor, master or MD thesis in basic and translational research.
We are hiring:
1 PhD Student Position in “Epitranscriptomics and Infection” (TV-L E13 65%) available.
If you are interested in joining the lab, please email a copy of your CV and a description of your research interests.