The Junior Research Group “Functional Host-Microbiome Research” was established in 2020. Our main focus is the role of the interactions between the host and its associated microorganisms – the microbiome. Microorganisms have historically been regarded solely as pathogens from which we need to protect ourselves from and to that end developed a sophisticated immune system. In the past years we and others have shown that we all live in close association with a vast diversity of microorganisms that not only contribute to various physiological processes including our immune responses, metabolism and even behavior, but also protect from pathogenic infections. Dysbiosis, meaning disturbances of these homeostatic host-microbiome interactions, are associated with a range of inflammatory, metabolic and other diseases. However, the involved molecular pathways and the functional impact of these associations largely remain to be elucidated. Our mission is to functionally understand the intricate and complex interactions between the host, its associated microbiome and environmental factors that together determine a healthy homeostasis of the metaorganism. A particular focus lies on selection mechanisms shaping the intestinal ecosystem and how the microbiome contributes to host metabolism (e.g. glycolysis) as well as immune responses along with dysregulation of these interactions during disease. These projects aim to develop novel strategies for treating common metabolic and inflammatory disorders by targeting the microbiome. To that end we employ a combination of gnotobiotic in vivo conditional knockout models, functional in vitro organoid systems and novel high-throughput “omics” technologies such as next generation sequencing or metabolomics.
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tbd., PhD student
Saskia Weber-Stiehl, master student
Zeynep Seker, master student
Lea Järke, MD student
Felix Gilbert, MD student
Jacob Hamm, MD student
Finn Hinrichsen, MD student
Kenneth Klischies, MD student
We are hiring:
The group is always interested in motivated students to conduct their bachelor, master or MD thesis in basic and translational research.
If you are interested in joining the lab, please email a copy of your CV and a description of your research interests.
We will soon also open a call for a PhD position. Stay tuned.
Work in our lab is supported by funding through the German Research Foundation (DFG) for the project “Role of DUOX2 in shaping the intestinal microbiota and effects on inflammation, cancer and metabolic disease” (SO1141/10-1) and within the framework of the Research Group “miTarget – The Microbiome as a Target in Inflammatory Bowel Diseases” (FOR5042), the Research Training Group “Genes, Environment and Inflammation” (RTG1743), the Excellence Cluster “Precision Medicine in Chronic Inflammation” (EXS2167) and the Collaborative Research Centre “Evolution and Function of Metaorganisms” (CRC1182).