Apolipoprotein E (APOE) is a plasma protein and a central mediator of lipid and lipoprotein metabolism. Its three isoforms E2, E3, and E4 are encoded by the alleles ε2, 3 and 4, respectively. In Western societies, APOE ε4 is associated with increased morbidity and mortality, and represents a significant risk factor for age-related disorders such as cardiovascular events or late-onset Alzheimer's disease. The ε4 allele occurs in approximately 14% of the general middle-aged German population. Several of our projects examined APOE genotype-dependent effects with an emphasis on evolutionary aspects. We are particularly interested in interactions between APOE genotype, dietary factors (e.g. caloric restriction) and ageing processes using APOE2, 3 and 4 gene targeted replacement mice.
Funded by: DFG Research Training Group Genes, Environment and Inflammation (2012-2015).