Molecular Signatures of Inflammatory Diseases

Facts & Details: 

The past few years brought decisive advances in sequencing technology that now allows analysis of whole genomes and transcriptomes at low costs and within a short period, typically 1 to 2 weeks. This technology allows a multitude of applications, including the in-depth analysis of genomics, transcriptomics, epigenomics and metagenomics. We use and combine these different layers to trace genetic changes and their consequences on the development and progress of human diseases to gain hypotheses for new directions in pathophysiology research. One of our foci is the analysis of genetic and epigenetic data related to inflammatory bowel disease. We are a member of several large-scale national and international consortia (ICGC, IHEC) aiming at the correlation of different layers of genetic and functional genomic information in the disease context. On the technological side, we are contributing to the development of low-input methods for RNA sequencing, bacterial community profiling/metatranscriptomics and metabolic labelling of RNA.

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