Prof. Bacher investigates the causes of immune-mediated diseases, such as chronic inflammatory bowel diseases, autoimmunity and allergies. Certain immune cells, so-called T-helper (Th) cells play a central role in the defense against pathogens. However, inappropriate or too strong immune reactions can also lead to diseases. How the protective immunity and tolerance is maintained or disturbed is not known in many clinical situations and is the focus of Dr. Bacher's research. Especially her two recent publications in the renowned scientific journal Cell about the antigen-specific regulation of allergic reactions against antigens from the air by regulatory T cells, as well as the protective Th17 immunity against the commensal mold Candida albicans, which at the same time promotes immunopathology against other fungal pathogens in patients with chronic lung diseases, represent fundamentally new insights in the understanding of human immunotolerance and immunopathology. These new findings enable the development of new and individualized therapeutic approaches for people suffering from chronic inflammatory bowel diseases, cystic fibrosis, obstructive pulmonary disease or asthma.
You can find PMI press release here (Sorry only in german)