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Institut für Klinische Molekularbiologie der Christian-Albrechts-Universität zu Kiel

Scientist

Eva Ellinghaus

Research Projects - Scientist

Childhood Leukemia Project

Genetic Association Analysis / GWAS

HLA Fine Mapping

HLA Typing

Research Group

Genetics & Bioinformatics

Contact

+49 (0) 431 / 500 - 15 138

e.ellinghaus [at] ikmb.uni-kiel.de

Research Interest

Eva Ellinghaus

Main Publications

Genome-wide association analysis for chronic venous disease identifies EFEMP1 and KCNH8 as susceptibility loci.
PubMed (PMID: 28374850) | 2017 | Scientific Reports
Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells.
PubMed (PMID: 25891430) | 2015 | Nature communications
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.
PubMed (PMID: 25559196) | 2015 | Nature genetics
Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling.
PubMed (PMID: 28973304) | 2017 | Human molecular genetics
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants.
PubMed (PMID: 28537254) | 2017 | Nature communications

Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility.
PubMed (PMID: 36038634) | 2022 | Nature genetics
Genetic Variation in ABCC4 and CFTR and Acute Pancreatitis during Treatment of Pediatric Acute Lymphoblastic Leukemia.
PubMed (PMID: 34768335) | 2021 | Journal of clinical medicine
Large-Scale Imputation of KIR Copy Number and HLA Alleles in North American and European Psoriasis Case-Control Cohorts Reveals Association of Inhibitory KIR2DL2 With Psoriasis.
PubMed (PMID: 34177931) | 2021 | Frontiers in immunology
Trans-ethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals shared but also ethnicity-specific disease associations.
PubMed (PMID: 33555323) | 2021 | Human molecular genetics
Whole-genome sequencing of a sporadic primary immunodeficiency cohort.
PubMed (PMID: 32499645) | 2020 | Nature : a weekly illustrated journal of science
Genome-wide association study of psoriasis in an Egyptian population.
PubMed (PMID: 30921485) | 2019 | Experimental dermatology
Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression.
PubMed (PMID: 31707051) | 2019 | Journal of allergy and clinical immunology
Construction and benchmarking of a multi-ethnic reference panel for the imputation of HLA class I and II alleles.
PubMed (PMID: 30590525) | 2018 | Human molecular genetics
Epidermal lipid composition, barrier integrity and eczematous inflammation are associated with skin microbiome configuration.
PubMed (PMID: 29421277) | 2018 | Journal of allergy and clinical immunology
Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with GUCY2C-linked familial diarrhea.
PubMed (PMID: 30353760) | 2018 | Scandinavian journal of gastroenterology
Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data.
PubMed (PMID: 30325587) | 2018 | American journal of medical genetics Part B, Neuropsychiatric genetics
Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients.
PubMed (PMID: 30301895) | 2018 | Nature communications
Predicting Humoral Alloimmunity from Differences in Donor and Recipient HLA Surface Electrostatic Potential.
PubMed (PMID: 30429288) | 2018 | The journal of immunology
Genetic association with B-cell acute lymphoblastic leukemia in allogeneic transplant patients differs by age and sex.
PubMed (PMID: 29296818) | 2017 | Blood advances
Microbiomarkers in inflammatory bowel diseases: caveats come with caviar.
PubMed (PMID: 28733278) | 2017 | Gut : journal of the British Society of Gastroenterology
A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology.
PubMed (PMID: 26868379) | 2016 | Nature communications
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
PubMed (PMID: 26974007) | 2016 | Nature genetics
CD4+ T cells from patients with primary sclerosing cholangitis exhibit reduced apoptosis and down-regulation of proapoptotic Bim in peripheral blood.
PubMed (PMID: 27630216) | 2016 | Journal of leukocyte biology. Supplement
Nonsyndromic cleft lip with or without cleft palate and cancer: Evaluation of a possible common genetic background through the analysis of GWAS data.
PubMed (PMID: 27630819) | 2016 | Genomics data
Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms.
PubMed (PMID: 25853426) | 2015 | PloS one
Correction: Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases Indicates Shared Molecular Genetic Mechanisms.
PubMed (PMID: 25978331) | 2015 | PloS one
Development of a high-resolution NGS-based HLA-typing and analysis pipeline.
PubMed (PMID: 25753671) | 2015 | Nucleic acids research
Enhanced meta-analysis and replication studies identify five new psoriasis susceptibility loci.
PubMed (PMID: 25939698) | 2015 | Nature communications
Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.
PubMed (PMID: 26626624) | 2015 | American journal of human genetics
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
PubMed (PMID: 25574825) | 2015 | American journal of human genetics
Genome-wide Comparative Analysis of Atopic Dermatitis and Psoriasis Gives Insight into Opposing Genetic Mechanisms.
PubMed (PMID: 0) | 2015 | American journal of human genetics
Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.
PubMed (PMID: 25903422) | 2015 | Nature communications
Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.
PubMed (PMID: 26214592) | 2015 | Nature genetics
Identification of Immune-relevant Factors Conferring Sarcoidosis Genetic Risk.
PubMed (PMID: 26051272) | 2015 | American journal of respiratory and critical care medicine
Imputation of KIR Types from SNP Variation Data.
PubMed (PMID: 26430804) | 2015 | American journal of human genetics
Childhood acute lymphoblastic leukemia-associated risk-loci IKZF1, ARID5B and CEBPE and risk of pediatric non-Hodgkin lymphoma: a report from the BFM Study Group.
PubMed (PMID: 25005032) | 2014 | Leukemia & Lymphoma
Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes.
PubMed (PMID: 25087609) | 2014 | American journal of human genetics
Reduced FOXP3(+) regulatory T cells in patients with primary sclerosing cholangitis are associated with IL2RA gene polymorphisms.
PubMed (PMID: 24412607) | 2014 | Journal of hepatology : the journal of the European Association for the Study of the Liver
Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies.
PubMed (PMID: 23624108) | 2013 | Gastroenterology (New York, N.Y. 1943)
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.
PubMed (PMID: 23603763) | 2013 | Nature genetics
Frequent and sex-biased deletion of SLX4IP by illegitimate V(D)J-mediated recombination in childhood acute lymphoblastic leukemia.
PubMed (PMID: 24045615) | 2013 | Human molecular genetics
Genome-wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4.
PubMed (PMID: 22821403) | 2013 | Hepatology : official journal of the American Association for the Study of Liver Diseases
Replication study of ulcerative colitis risk loci in a Lithuanian-Latvian case-control sample.
PubMed (PMID: 23974994) | 2013 | Inflammatory bowel diseases
Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci.
PubMed (PMID: 22482804) | 2012 | American journal of human genetics
Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis.
PubMed (PMID: 22914738) | 2012 | Human molecular genetics
Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci.
PubMed (PMID: 22521342) | 2012 | Journal of hepatology : the journal of the European Association for the Study of the Liver
Fine mapping and replication of genetic risk loci in primary sclerosing cholangitis.
PubMed (PMID: 22554193) | 2012 | Scandinavian journal of gastroenterology
Genome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL.
PubMed (PMID: 22170493) | 2012 | Journal of investigative dermatology
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
PubMed (PMID: 23143594) | 2012 | Nature genetics
Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.
PubMed (PMID: 22076464) | 2012 | Leukemia
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.
PubMed (PMID: 21151127) | 2011 | Nature genetics
Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9.
PubMed (PMID: 21425313) | 2011 | Hepatology : official journal of the American Association for the Study of Liver Diseases
Association analyses identify six new psoriasis susceptibility loci in the Chinese population.
PubMed (PMID: 20953187) | 2010 | Nature genetics
Association to the Glypican-5 gene in multiple sclerosis.
PubMed (PMID: 20692050) | 2010 | Journal of neuroimmunology : official bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology
Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eQTL signals.
PubMed (PMID: 21129726) | 2010 | American journal of human genetics
Genome-wide association analysis identifies three psoriasis susceptibility loci.
PubMed (PMID: 20953189) | 2010 | Nature genetics
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).
PubMed (PMID: 20228798) | 2010 | Nature genetics
Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.
PubMed (PMID: 20953188) | 2010 | Nature genetics
Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis.
PubMed (PMID: 20811628) | 2010 | PloS one

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