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Institut für Klinische Molekularbiologie der Christian-Albrechts-Universität zu Kiel

Scientist

Georg Hemmrich-Stanisak

Research Projects - Scientist

Clinical Data Management

Data Management & LIMS

High Resolution 3D Stereo Light Microscopy

microRNA Research

Research Group

Genetics & Bioinformatics

Contact

+49 (0) 431 / 500 - 15 141

g.hemmrich-stanisak [at] ikmb.uni-kiel.de

Research Interest

Dissertation - 2007, University of Kiel

Main Publications

A comprehensive, cell specific microRNA catalogue of human peripheral blood.
PubMed (PMID: 28934507) | 2017 | Nucleic acids research
Genomewide Association Study of Severe Covid-19 with Respiratory Failure.
PubMed (PMID: 32558485) | 2020 | New England journal of medicine
Depletion of erythropoietic miR-486-5p and miR-451a improves detectability of rare microRNAs in peripheral blood-derived small RNA sequencing libraries
PubMed (PMID: 0) | 2020 | NAR Genomics and Bioinformatics
Sparse Modeling Reveals miRNA Signatures for Diagnostics of Inflammatory Bowel Disease.
PubMed (PMID: 26466382) | 2015 | PloS one
Comprehensive analysis of microRNA profiles in multiple sclerosis including next-generation sequencing.
PubMed (PMID: 23836875) | 2013 | Multiple sclerosis : clinical and laboratory research

Detailed stratified GWAS analysis for severe COVID-19 in four European populations.
PubMed (PMID: 35848942) | 2022 | Human molecular genetics
Detailed transcriptional landscape of peripheral blood points to increased neutrophil activation in treatment-naïve inflammatory bowel disease.
PubMed (PMID: 35022690) | 2022 | Journal of Crohn's & colitis : international journal devoted to inflammatory bowel diseases
Genomic characterization of the world's longest selection experiment in mouse reveals the complexity of polygenic traits.
PubMed (PMID: 35189878) | 2022 | BMC biology
miRNome Profiling and Functional Analysis Reveal Involvement of hsa-miR-1246 in Colon Adenoma-Carcinoma Transition by Targeting AXIN2 and CFTR.
PubMed (PMID: 35216222) | 2022 | International journal of molecular sciences
Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease.
PubMed (PMID: 33888516) | 2021 | Gut : journal of the British Society of Gastroenterology
Depletion of erythropoietic miR-486-5p and miR-451a improves detectability of rare microRNAs in peripheral blood-derived small RNA sequencing libraries.
PubMed (PMID: 33575555) | 2020 | NAR Genomics and Bioinformatics
Towards a European health research and innovation cloud (HRIC).
PubMed (PMID: 32075696) | 2020 | Genome medicine
Analysis of long non-coding RNA and mRNA expression in bovine macrophages brings up novel aspects of Mycobacterium avium subspecies paratuberculosis infections.
PubMed (PMID: 30733564) | 2019 | Scientific Reports
Integrating Culture-based Antibiotic Resistance Profiles with Whole-genome Sequencing Data for 11,087 Clinical Isolates.
PubMed (PMID: 31100356) | 2019 | Genomics, proteomics & bioinformatics
NGS-based methylation profiling differentiates TCF3-HLF and TCF3-PBX1 positive B-cell acute lymphoblastic leukemia.
PubMed (PMID: 29334255) | 2018 | Epigenomics
RNA based individualized drug selection in breast cancer patients without patient-matched normal tissue.
PubMed (PMID: 30190792) | 2018 | Oncotarget
Association mapping of morphological traits in wild and captive zebra finches: reliable within but not between populations.
PubMed (PMID: 28100011) | 2017 | Molecular ecology
MiRNA profiling of gastrointestinal stromal tumors by next-generation sequencing.
PubMed (PMID: 28402935) | 2017 | Oncotarget
Comparing genome versus proteome-based identification of clinical bacterial isolates.
PubMed (PMID: 28013236) | 2016 | Briefings in bioinformatics
Fitness consequences of polymorphic inversions in the zebra finch genome.
PubMed (PMID: 27687629) | 2016 | Genome biology
MicroRNA Response of Primary Human Macrophages to Arcobacter Butzleri Infection.
PubMed (PMID: 27429792) | 2016 | European journal of microbiology & immunology
Neuromuscular endplate pathology in recessive desminopathies: Lessons from man and mice.
PubMed (PMID: 27440146) | 2016 | Neurology
Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.
PubMed (PMID: 26214592) | 2015 | Nature genetics
Quantifying realized inbreeding in wild and captive animal populations.
PubMed (PMID: 25585923) | 2015 | Heredity : an international journal of genetics
Vy-PER: eliminating false positive detection of virus integration events in next generation sequencing data.
PubMed (PMID: 26166306) | 2015 | Scientific Reports
Regulation of polyp-to-jellyfish transition in Aurelia aurita.
PubMed (PMID: 24440392) | 2014 | CB : current biology : dispatches from the front lines of biology
FoxO is a critical regulator of stem cell maintenance in immortal Hydra: Proceedings of the National Academy of Sciences: Vol. 109, pp. 19697-19702, 2012.
PubMed (PMID: 25206004) | 2013 | Annals of neurosciences
From next-generation sequencing alignments to accurate comparison and validation of single-nucleotide variants: the pibase software.
PubMed (PMID: 22965131) | 2013 | Nucleic acids research
Identification and characterization of a defect CYP3A4 genotype in a kidney transplant patient with severely diminished tacrolimus clearance.
PubMed (PMID: 24126681) | 2013 | Clinical pharmacology and therapeutics : official publication of the American Therapeutic Society
FoxO is a critical regulator of stem cell maintenance in immortal Hydra.
PubMed (PMID: 23150562) | 2012 | Proceedings of the National Academy of Sciences of the United States of America
Molecular signatures of the three stem cell lineages in hydra and the emergence of stem cell function at the base of multicellularity.
PubMed (PMID: 22595987) | 2012 | Molecular biology and evolution
Defining the origins of the NOD-like receptor system at the base of animal evolution.
PubMed (PMID: 21183612) | 2011 | Molecular biology and evolution
Phylogenomics reveals an anomalous distribution of USP genes in metazoans.
PubMed (PMID: 20660083) | 2011 | Molecular biology and evolution
Nematogalectin, a nematocyst protein with GlyXY and galectin domains, demonstrates nematocyte-specific alternative splicing in Hydra.
PubMed (PMID: 20937891) | 2010 | Proceedings of the National Academy of Sciences of the United States of America
The dynamic genome of Hydra.
PubMed (PMID: 20228792) | 2010 | Nature : a weekly illustrated journal of science
The Hydra polyp: nothing but an active stem cell community.
PubMed (PMID: 19891641) | 2010 | Development, growth & differentiation
Activity of the novel peptide arminin against multiresistant human pathogens shows the considerable potential of phylogenetically ancient organisms as drug sources.
PubMed (PMID: 19770277) | 2009 | Antimicrobial agents and chemotherapy
Characterization of taxonomically restricted genes in a phylum-restricted cell type.
PubMed (PMID: 19161630) | 2009 | Genome biology
More than just orphans: are taxonomically-restricted genes important in evolution?
PubMed (PMID: 19716618) | 2009 | Trends in genetics (Monthly edition)
Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence.
PubMed (PMID: 19013190) | 2009 | Developmental and comparative immunology : an international journal on immunological diversification
A novel gene family controls species-specific morphological traits in Hydra.
PubMed (PMID: 19018660) | 2008 | PLoS biology / Public Library of Science
Compagen, a comparative genomics platform for early branching metazoan animals, reveals early origins of genes regulating stem-cell differentiation.
PubMed (PMID: 18800383) | 2008 | BioEssays
Allorecognition in urochordates: identification of a highly variable complement receptor-like protein expressed in follicle cells of Ciona.
PubMed (PMID: 17074389) | 2007 | Developmental and comparative immunology : an international journal on immunological diversification
Molecular phylogenetics in Hydra, a classical model in evolutionary developmental biology.
PubMed (PMID: 17174108) | 2007 | Molecular phylogenetics and evolution
The evolution of immunity: a low-life perspective.
PubMed (PMID: 17855167) | 2007 | Trends in immunology
The innate immune repertoire in cnidaria--ancestral complexity and stochastic gene loss.
PubMed (PMID: 17437634) | 2007 | Genome biology
Transgenic stem cells in Hydra reveal an early evolutionary origin for key elements controlling self-renewal and differentiation.
PubMed (PMID: 17659272) | 2007 | Developmental biology
Dickkopf related genes are components of the positional value gradient in Hydra.
PubMed (PMID: 16806155) | 2006 | Developmental biology
Discovery of genes expressed in Hydra embryogenesis.
PubMed (PMID: 16337937) | 2006 | Developmental biology

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