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Institut für Klinische Molekularbiologie der Christian-Albrechts-Universität zu Kiel

Clinical Senior Scientist / Junior Research Group

Konrad Aden

Research Projects - Scientist

Epithelial biology and stress response in IBD

Intestinal Immunometabolism

Microbial sensing and co-metabolism

Precision therapy in IBD

Research Group

Junior Research Groups Systems Immunology

Contact

+49 (0) 431 / 500 - 22 455

k.aden [at] ikmb.uni-kiel.de

Research Interest

Konrad Aden

Main Publications

A gut bacterial signature in blood and liver tissue characterizes cirrhosis and hepatocellular carcinoma.
PubMed (PMID: 37314752) | 2023 | Hepatology communications
Amino acid auxotrophies in human gut bacteria are linked to higher microbiome diversity and long-term stability.
PubMed (PMID: 37891427) | 2023 | The ISME journal
Fibrosis and Inflammation in Inflammatory Bowel Disease-More Than 2 Sides of the Same Coin?
PubMed (PMID: 36341736) | 2023 | Gastroenterology (New York, N.Y. 1943)
Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic T_H1 cell responses in Crohn's disease.
PubMed (PMID: 37749331) | 2023 | Nature medicine
A novel unconventional T cell population enriched in Crohn's disease.
PubMed (PMID: 35264446) | 2022 | Gut : journal of the British Society of Gastroenterology

Distinct Longitudinal Changes in Immunoglobulin G N-Glycosylation Associate with Therapy Response in Chronic Inflammatory Diseases.
PubMed (PMID: 35955616) | 2022 | International journal of molecular sciences
DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon.
PubMed (PMID: 36271073) | 2022 | Nature communications
Interobserver reliability of the Nancy index for ulcerative colitis: An assessment of the practicability and ease of use in a single-centre real-world setting.
PubMed (PMID: 36282973) | 2022 | Journal of Crohn's & colitis : international journal devoted to inflammatory bowel diseases
Longitudinal monitoring of STAT3 phosphorylation and histologic outcome of tofacitinib therapy in patients with ulcerative colitis.
PubMed (PMID: 35484689) | 2022 | Alimentary pharmacology & therapeutics
Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease.
PubMed (PMID: 36153599) | 2022 | Genome medicine
MCPIP-1-Mediated Immunosuppression of Neutrophils Exacerbates Acute Bacterial Peritonitis and Liver Injury.
PubMed (PMID: 36273448) | 2022 | Journal of innate immunity
Publisher Correction: Signatures of TOP1 transcription-associated mutagenesis in cancer and germline.
PubMed (PMID: 35504971) | 2022 | Nature : a weekly illustrated journal of science
PUFA-induced metabolic enteritis as a fuel for Crohn's disease.
PubMed (PMID: 35031299) | 2022 | Gastroenterology (New York, N.Y. 1943)
Signatures of TOP1 transcription-associated mutagenesis in cancer and germline.
PubMed (PMID: 35140396) | 2022 | Nature : a weekly illustrated journal of science
Epithelial X-Box Binding Protein 1 Coordinates Tumor Protein p53-Driven DNA Damage Responses and Suppression of Intestinal Carcinogenesis.
PubMed (PMID: 34599932) | 2021 | Gastroenterology (New York, N.Y. 1943)
IL23R on myeloid cells is involved in murine pulmonary granuloma formation.
PubMed (PMID: 34405744) | 2021 | Experimental lung research
Microbial Butyrate Synthesis Indicates Therapeutic Efficacy of Azathioprine in IBD Patients.
PubMed (PMID: 32687146) | 2021 | Journal of Crohn's & colitis : international journal devoted to inflammatory bowel diseases
Subclinical Pulmonary Involvement in Active IBD Responds to Biologic Therapy.
PubMed (PMID: 33544122) | 2021 | Journal of Crohn's & colitis : international journal devoted to inflammatory bowel diseases
The role of cGAS/STING in intestinal immunity.
PubMed (PMID: 33577080) | 2021 | European journal of immunology
Therapeutic IL-6 trans-signalling inhibition by olamkicept (sgp130Fc) in patients with active inflammatory bowel disease.
PubMed (PMID: 33667488) | 2021 | Gastroenterology (New York, N.Y. 1943)
Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress.
PubMed (PMID: 32673694) | 2020 | Gastroenterology (New York, N.Y. 1943)
NOD2 influences trajectories of intestinal microbiota recovery after antibiotic perturbation.
PubMed (PMID: 32289499) | 2020 | Cellular and molecular gastroenterology and hepatology
Reply.
PubMed (PMID: 32068024) | 2020 | Gastroenterology (New York, N.Y. 1943)
SETDB1 is required for intestinal epithelial differentiation and the prevention of intestinal inflammation.
PubMed (PMID: 32503845) | 2020 | Gut : journal of the British Society of Gastroenterology
Interferon Lambda Promotes Paneth Cell Death Via STAT1 Signaling in Mice and Is Increased in Inflamed Ileal Tissues of Patients With Crohn's Disease.
PubMed (PMID: 31352002) | 2019 | Gastroenterology (New York, N.Y. 1943)
Metabolic Functions of Gut Microbes Associate With Efficacy of Tumor Necrosis Factor Antagonists in Patients with Inflammatory Bowel Diseases.
PubMed (PMID: 31326413) | 2019 | Gastroenterology (New York, N.Y. 1943)
Missense variants in NOX1 and p22phox in a case of very-early-onset inflammatory bowel disease are functionally linked to NOD2.
PubMed (PMID: 30709874) | 2019 | Cold Spring Harbor molecular case studies
Prdx4 limits caspase-1 activation and restricts inflammasome-mediated signaling by extracellular vesicles.
PubMed (PMID: 31544965) | 2019 | The EMBO journal
The Gut Microbiome in Inflammatory Bowel Diseases: Diagnostic and Therapeutic Implications.
PubMed (PMID: 31934579) | 2019 | Visceral medicine
ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.
PubMed (PMID: 30254094) | 2018 | The journal of experimental medicine
Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice.
PubMed (PMID: 30273559) | 2018 | Gastroenterology (New York, N.Y. 1943)
Vedolizumab is associated with changes in innate rather than adaptive immunity in patients with inflammatory bowel disease.
PubMed (PMID: 29730603) | 2018 | Gut : journal of the British Society of Gastroenterology
Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy.
PubMed (PMID: 29016854) | 2017 | Human molecular genetics
Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases.
PubMed (PMID: 28827067) | 2017 | Gastroenterology (New York, N.Y. 1943)
Microbiomarkers in inflammatory bowel diseases: caveats come with caviar.
PubMed (PMID: 28733278) | 2017 | Gut : journal of the British Society of Gastroenterology
The Dark Age(ing) of the Inflammasome.
PubMed (PMID: 28228276) | 2017 | Immunity (Cambridge, Mass.)
Classic IL-6R signalling is dispensable for intestinal epithelial proliferation and repair.
PubMed (PMID: 27869785) | 2016 | Oncogenesis
Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation.
PubMed (PMID: 27524624) | 2016 | Cell reports
Uncoupling of mucosal gene regulation, mRNA splicing and adherent microbiota signatures in inflammatory bowel disease.
PubMed (PMID: 27694142) | 2016 | Gut : journal of the British Society of Gastroenterology
PWE-110 A Role For Peroxiredoxin-4 In A Murine Colitis Model Of Intestinal Inflammation.
PubMed (PMID: 25021599) | 2014 | Gut : journal of the British Society of Gastroenterology
Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice.
PubMed (PMID: 22442160) | 2013 | Gut : journal of the British Society of Gastroenterology
Modulation of Nuclear factor E2 related factor-2 (Nrf2) activation by the stress response gene Immediate Early Response-3 (IER3) in colonic epithelial cells - a novel mechanism of cellular adaption to inflammatory stress.
PubMed (PMID: 24311782) | 2013 | JBC papers in press
RNAi screening identifies mediators of NOD2 signaling: implications for spatial specificity of MDP recognition.
PubMed (PMID: 23213202) | 2012 | Proceedings of the National Academy of Sciences of the United States of America
Toll-like receptor-7 ligand Imiquimod induces type I interferon and antimicrobial peptides to ameliorate dextran sodium sulfate-induced acute colitis.
PubMed (PMID: 21953855) | 2012 | Inflammatory bowel diseases
Reg IV regulates normal intestinal and colorectal cancer cell susceptibility to radiation-induced apoptosis.
PubMed (PMID: 19900450) | 2010 | Gastroenterology (New York, N.Y. 1943)

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