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Institut für Klinische Molekularbiologie der Christian-Albrechts-Universität zu Kiel

Scientist

Malte Rühlemann

Research Group

Genetics & Bioinformatics

Contact

+49 (0) 431 / 500 - 15 132

m.ruehlemann [at] ikmb.uni-kiel.de

Research Interest

Malte Rühlemann

Main Publications

Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome.
PubMed (PMID: 33462482) | 2021 | Nature genetics
Consistent alterations in faecal microbiomes of patients with primary sclerosing cholangitis independent of associated colitis.
PubMed (PMID: 31250469) | 2019 | Alimentary pharmacology & therapeutics
Microbiomarkers in inflammatory bowel diseases: caveats come with caviar.
PubMed (PMID: 28733278) | 2017 | Gut : journal of the British Society of Gastroenterology
Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition.
PubMed (PMID: 31399369) | 2019 | Cell host & microbe
Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis.
PubMed (PMID: 28604703) | 2017 | Nature medicine

Linkage analysis identifies novel genetic modifiers of microbiome traits in families with inflammatory bowel disease.
PubMed (PMID: 35129060) | 2022 | Gut microbes
NMR Metabolomics Reveal Urine Markers of Microbiome Diversity and Identify Benzoate Metabolism as a Mediator between High Microbial Alpha Diversity and Metabolic Health.
PubMed (PMID: 35448495) | 2022 | Metabolites
Carrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis.
PubMed (PMID: 33758296) | 2021 | Scientific Reports
Ecology impacts the decrease of Spirochaetes and Prevotella in the fecal gut microbiota of urban humans.
PubMed (PMID: 34635060) | 2021 | BMC microbiology
Exocrine Pancreatic Function Modulates Plasma Metabolites Through Changes in Gut Microbiota Composition.
PubMed (PMID: 33462612) | 2021 | The Journal of clinical endocrinology and metabolism
Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease.
PubMed (PMID: 33888516) | 2021 | Gut : journal of the British Society of Gastroenterology
Intestinal protozoan infections shape fecal bacterial microbiota in children from Guinea-Bissau.
PubMed (PMID: 33657123) | 2021 | PLoS neglected tropical diseases / Public Library of Science
Large-scale association analyses identify host factors influencing human gut microbiome composition.
PubMed (PMID: 33462485) | 2021 | Nature genetics
Primate phageomes are structured by superhost phylogeny and environment.
PubMed (PMID: 33876746) | 2021 | Proceedings of the National Academy of Sciences of the United States of America
Reporting guidelines for human microbiome research: the STORMS checklist.
PubMed (PMID: 34789871) | 2021 | Nature medicine
Short-term physical exercise impacts on the human holobiont obtained by a randomised intervention study.
PubMed (PMID: 34078289) | 2021 | BMC microbiology
Targeting the cytoplasmic polyadenylation element-binding protein CPEB4 protects against diet-induced obesity and microbiome dysbiosis.
PubMed (PMID: 34774811) | 2021 | Molecular metabolism
A disease-specific decline of the relative abundance of Bifidobacterium in patients with autoimmune hepatitis.
PubMed (PMID: 32383181) | 2020 | Alimentary pharmacology & therapeutics
A fungal pathogen induces systemic susceptibility and systemic shifts in wheat metabolome and microbiome composition.
PubMed (PMID: 32313046) | 2020 | Nature communications
Altered gut microbial metabolism of essential nutrients in primary sclerosing cholangitis.
PubMed (PMID: 33387530) | 2020 | Gastroenterology (New York, N.Y. 1943)
Comparative Studies of the Gut Microbiota in the Offspring of Mothers With and Without Gestational Diabetes.
PubMed (PMID: 33194786) | 2020 | Frontiers in Cellular and Infection Microbiology
Differences in the microbiota of native and non-indigenous gelatinous zooplankton organisms in a low saline environment.
PubMed (PMID: 32464382) | 2020 | The science of the total environment : an international journal for scientific research into the environment and its relationship with man / Society for Environmental Geochemistry and Health
Genome-wide associations of human gut microbiome variation and implications for causal inference analyses.
PubMed (PMID: 32572223) | 2020 | Nature microbiology
Genomewide Association Study of Severe Covid-19 with Respiratory Failure.
PubMed (PMID: 32558485) | 2020 | New England journal of medicine
IL-22 Paucity in APECED Is Associated With Mucosal and Microbial Alterations in Oral Cavity.
PubMed (PMID: 32477345) | 2020 | Frontiers in immunology
Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function.
PubMed (PMID: 33168600) | 2020 | Gut : journal of the British Society of Gastroenterology
The Gut Microbiome in Patients With Chronic Pancreatitis Is Characterized by Significant Dysbiosis and Overgrowth by Opportunistic Pathogens.
PubMed (PMID: 33094959) | 2020 | Clinical and translational gastroenterology
A structured weight loss program increases gut microbiota phylogenetic diversity and reduces levels of Collinsella in obese type 2 diabetics: A pilot study.
PubMed (PMID: 31318902) | 2019 | PloS one
Alterations of the bile microbiome in primary sclerosing cholangitis.
PubMed (PMID: 31243055) | 2019 | Gut : journal of the British Society of Gastroenterology
Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms.
PubMed (PMID: 31521200) | 2019 | Microbiome
Editorial: gut microbial profile associated with primary sclerosing cholangitis-what is new and how do we progress from here? Authors' reply.
PubMed (PMID: 31414547) | 2019 | Alimentary pharmacology & therapeutics
Gut mycobiome of primary sclerosing cholangitis patients is characterised by an increase of Trichocladium griseum and Candida species.
PubMed (PMID: 31653787) | 2019 | Gut : journal of the British Society of Gastroenterology
Helicobacter pylori infection associates with fecal microbiota composition and diversity.
PubMed (PMID: 31882864) | 2019 | Scientific Reports
Minor compositional alterations in faecal microbiota after five weeks and five months storage at room temperature on filter papers.
PubMed (PMID: 31831829) | 2019 | Scientific Reports
Normal gut microbiome in NMDA receptor encephalitis.
PubMed (PMID: 31624178) | 2019 | Neurology(R) neuroimmunology & neuroinflammation
Pseudomonas aeruginosa populations in the cystic fibrosis lung lose susceptibility to newly applied β-lactams within 3 days.
PubMed (PMID: 31355848) | 2019 | The Journal of antimicrobial chemotherapy
Epidermal lipid composition, barrier integrity and eczematous inflammation are associated with skin microbiome configuration.
PubMed (PMID: 29421277) | 2018 | Journal of allergy and clinical immunology
Functional abdominal pain and discomfort (IBS) is not associated with faecal microbiota composition in the general population.
PubMed (PMID: 29860240) | 2018 | Gut : journal of the British Society of Gastroenterology
Functions of the Microbiota for the Physiology of Animal Metaorganisms.
PubMed (PMID: 30566939) | 2018 | Journal of innate immunity
Gestational diabetes is associated with change in the gut microbiota composition in third trimester of pregnancy and postpartum.
PubMed (PMID: 29764499) | 2018 | Microbiome
Impaired Exocrine Pancreatic Function Associates With Changes in Intestinal Microbiota Composition and Diversity.
PubMed (PMID: 30391469) | 2018 | Gastroenterology (New York, N.Y. 1943)
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.
PubMed (PMID: 29880062) | 2018 | Microbiome
Sucrase-isomaltase 15Phe IBS risk variant in relation to dietary carbohydrates and faecal microbiota composition.
PubMed (PMID: 29331942) | 2018 | Gut : journal of the British Society of Gastroenterology
Application of the distance-based F test in an mGWAS investigating beta diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and three other loci.
PubMed (PMID: 28816579) | 2017 | Gut microbes
Functional sequencing read annotation for high precision microbiome analysis.
PubMed (PMID: 29194524) | 2017 | Nucleic acids research
Heart failure is associated with depletion of core intestinal microbiota.
PubMed (PMID: 28772054) | 2017 | ESC Heart Failure
Beneficial Effects of a Dietary Weight Loss Intervention on Human Gut Microbiome Diversity and Metabolism Are Not Sustained during Weight Maintenance.
PubMed (PMID: 27898428) | 2016 | Obesity facts
Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis.
PubMed (PMID: 27216937) | 2016 | Gut : journal of the British Society of Gastroenterology
Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.
PubMed (PMID: 27723756) | 2016 | Nature genetics
Interdisciplinary approach towards a systems medicine toolbox using the example of inflammatory diseases.
PubMed (PMID: 27016392) | 2016 | Briefings in bioinformatics
Paternal chronic colitis causes epigenetic inheritance of susceptibility to colitis.
PubMed (PMID: 27538787) | 2016 | Scientific Reports
Vy-PER: eliminating false positive detection of virus integration events in next generation sequencing data.
PubMed (PMID: 26166306) | 2015 | Scientific Reports

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