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Institut für Klinische Molekularbiologie der Christian-Albrechts-Universität zu Kiel

Scientist

Malte Rühlemann

Research Group

Genetics & Bioinformatics

Contact

+49 (0) 431 / 500 - 15 132

m.ruehlemann [at] ikmb.uni-kiel.de

Research Interest

Malte Rühlemann

Main Publications

Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome.
PubMed (PMID: 33462482) | 2021 | Nature genetics
Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition.
PubMed (PMID: 31399369) | 2019 | Cell host & microbe
MAGScoT - a fast, lightweight, and accurate bin-refinement tool.
PubMed (PMID: 36264141) | 2022 | Bioinformatics
Primate phageomes are structured by superhost phylogeny and environment.
PubMed (PMID: 33876746) | 2021 | Proceedings of the National Academy of Sciences of the United States of America
Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota.
PubMed (PMID: 36261456) | 2022 | Nature communications

Activated regulatory T-cells promote duodenal bacterial translocation into necrotic areas in severe acute pancreatitis.
PubMed (PMID: 36631247) | 2023 | Gut : journal of the British Society of Gastroenterology
Impaired Abcb1a function and red meat in a translational colitis mouse model induces inflammation and alters microbiota composition.
PubMed (PMID: 37588005) | 2023 | Frontiers in medicine
Network-based quantitative trait linkage analysis of microbiome composition in inflammatory bowel disease families.
PubMed (PMID: 36755569) | 2023 | Frontiers in genetics
Detailed stratified GWAS analysis for severe COVID-19 in four European populations.
PubMed (PMID: 35848942) | 2022 | Human molecular genetics
Key features of the genetic architecture and evolution of host-microbe interactions revealed by high-resolution genetic mapping of the mucosa-associated gut microbiome in hybrid mice.
PubMed (PMID: 35866635) | 2022 | eLife
Linkage analysis identifies novel genetic modifiers of microbiome traits in families with inflammatory bowel disease.
PubMed (PMID: 35129060) | 2022 | Gut microbes
NMR Metabolomics Reveal Urine Markers of Microbiome Diversity and Identify Benzoate Metabolism as a Mediator between High Microbial Alpha Diversity and Metabolic Health.
PubMed (PMID: 35448495) | 2022 | Metabolites
Carrying asymptomatic gallstones is not associated with changes in intestinal microbiota composition and diversity but cholecystectomy with significant dysbiosis.
PubMed (PMID: 33758296) | 2021 | Scientific Reports
Ecology impacts the decrease of Spirochaetes and Prevotella in the fecal gut microbiota of urban humans.
PubMed (PMID: 34635060) | 2021 | BMC microbiology
Exocrine Pancreatic Function Modulates Plasma Metabolites Through Changes in Gut Microbiota Composition.
PubMed (PMID: 33462612) | 2021 | The Journal of clinical endocrinology and metabolism
Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease.
PubMed (PMID: 33888516) | 2021 | Gut : journal of the British Society of Gastroenterology
Intestinal protozoan infections shape fecal bacterial microbiota in children from Guinea-Bissau.
PubMed (PMID: 33657123) | 2021 | PLoS neglected tropical diseases / Public Library of Science
Large-scale association analyses identify host factors influencing human gut microbiome composition.
PubMed (PMID: 33462485) | 2021 | Nature genetics
Reporting guidelines for human microbiome research: the STORMS checklist.
PubMed (PMID: 34789871) | 2021 | Nature medicine
Short-term physical exercise impacts on the human holobiont obtained by a randomised intervention study.
PubMed (PMID: 34078289) | 2021 | BMC microbiology
Targeting the cytoplasmic polyadenylation element-binding protein CPEB4 protects against diet-induced obesity and microbiome dysbiosis.
PubMed (PMID: 34774811) | 2021 | Molecular metabolism
A disease-specific decline of the relative abundance of Bifidobacterium in patients with autoimmune hepatitis.
PubMed (PMID: 32383181) | 2020 | Alimentary pharmacology & therapeutics
A fungal pathogen induces systemic susceptibility and systemic shifts in wheat metabolome and microbiome composition.
PubMed (PMID: 32313046) | 2020 | Nature communications
Altered gut microbial metabolism of essential nutrients in primary sclerosing cholangitis.
PubMed (PMID: 33387530) | 2020 | Gastroenterology (New York, N.Y. 1943)
Comparative Studies of the Gut Microbiota in the Offspring of Mothers With and Without Gestational Diabetes.
PubMed (PMID: 33194786) | 2020 | Frontiers in Cellular and Infection Microbiology
Differences in the microbiota of native and non-indigenous gelatinous zooplankton organisms in a low saline environment.
PubMed (PMID: 32464382) | 2020 | The science of the total environment : an international journal for scientific research into the environment and its relationship with man / Society for Environmental Geochemistry and Health
Genome-wide associations of human gut microbiome variation and implications for causal inference analyses.
PubMed (PMID: 32572223) | 2020 | Nature microbiology
Genomewide Association Study of Severe Covid-19 with Respiratory Failure.
PubMed (PMID: 32558485) | 2020 | New England journal of medicine
IL-22 Paucity in APECED Is Associated With Mucosal and Microbial Alterations in Oral Cavity.
PubMed (PMID: 32477345) | 2020 | Frontiers in immunology
Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function.
PubMed (PMID: 33168600) | 2020 | Gut : journal of the British Society of Gastroenterology
The Gut Microbiome in Patients With Chronic Pancreatitis Is Characterized by Significant Dysbiosis and Overgrowth by Opportunistic Pathogens.
PubMed (PMID: 33094959) | 2020 | Clinical and translational gastroenterology
A structured weight loss program increases gut microbiota phylogenetic diversity and reduces levels of Collinsella in obese type 2 diabetics: A pilot study.
PubMed (PMID: 31318902) | 2019 | PloS one
Alterations of the bile microbiome in primary sclerosing cholangitis.
PubMed (PMID: 31243055) | 2019 | Gut : journal of the British Society of Gastroenterology
Comparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms.
PubMed (PMID: 31521200) | 2019 | Microbiome
Consistent alterations in faecal microbiomes of patients with primary sclerosing cholangitis independent of associated colitis.
PubMed (PMID: 31250469) | 2019 | Alimentary pharmacology & therapeutics
Editorial: gut microbial profile associated with primary sclerosing cholangitis-what is new and how do we progress from here? Authors' reply.
PubMed (PMID: 31414547) | 2019 | Alimentary pharmacology & therapeutics
Gut mycobiome of primary sclerosing cholangitis patients is characterised by an increase of Trichocladium griseum and Candida species.
PubMed (PMID: 31653787) | 2019 | Gut : journal of the British Society of Gastroenterology
Helicobacter pylori infection associates with fecal microbiota composition and diversity.
PubMed (PMID: 31882864) | 2019 | Scientific Reports
Minor compositional alterations in faecal microbiota after five weeks and five months storage at room temperature on filter papers.
PubMed (PMID: 31831829) | 2019 | Scientific Reports
Normal gut microbiome in NMDA receptor encephalitis.
PubMed (PMID: 31624178) | 2019 | Neurology(R) neuroimmunology & neuroinflammation
Pseudomonas aeruginosa populations in the cystic fibrosis lung lose susceptibility to newly applied β-lactams within 3 days.
PubMed (PMID: 31355848) | 2019 | The Journal of antimicrobial chemotherapy
Epidermal lipid composition, barrier integrity and eczematous inflammation are associated with skin microbiome configuration.
PubMed (PMID: 29421277) | 2018 | Journal of allergy and clinical immunology
Functional abdominal pain and discomfort (IBS) is not associated with faecal microbiota composition in the general population.
PubMed (PMID: 29860240) | 2018 | Gut : journal of the British Society of Gastroenterology
Functions of the Microbiota for the Physiology of Animal Metaorganisms.
PubMed (PMID: 30566939) | 2018 | Journal of innate immunity
Gestational diabetes is associated with change in the gut microbiota composition in third trimester of pregnancy and postpartum.
PubMed (PMID: 29764499) | 2018 | Microbiome
Impaired Exocrine Pancreatic Function Associates With Changes in Intestinal Microbiota Composition and Diversity.
PubMed (PMID: 30391469) | 2018 | Gastroenterology (New York, N.Y. 1943)
Meta-analysis of human genome-microbiome association studies: the MiBioGen consortium initiative.
PubMed (PMID: 29880062) | 2018 | Microbiome
Sucrase-isomaltase 15Phe IBS risk variant in relation to dietary carbohydrates and faecal microbiota composition.
PubMed (PMID: 29331942) | 2018 | Gut : journal of the British Society of Gastroenterology
Application of the distance-based F test in an mGWAS investigating beta diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and three other loci.
PubMed (PMID: 28816579) | 2017 | Gut microbes
Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis.
PubMed (PMID: 28604703) | 2017 | Nature medicine
Functional sequencing read annotation for high precision microbiome analysis.
PubMed (PMID: 29194524) | 2017 | Nucleic acids research
Heart failure is associated with depletion of core intestinal microbiota.
PubMed (PMID: 28772054) | 2017 | ESC Heart Failure
Microbiomarkers in inflammatory bowel diseases: caveats come with caviar.
PubMed (PMID: 28733278) | 2017 | Gut : journal of the British Society of Gastroenterology
Beneficial Effects of a Dietary Weight Loss Intervention on Human Gut Microbiome Diversity and Metabolism Are Not Sustained during Weight Maintenance.
PubMed (PMID: 27898428) | 2016 | Obesity facts
Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis.
PubMed (PMID: 27216937) | 2016 | Gut : journal of the British Society of Gastroenterology
Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.
PubMed (PMID: 27723756) | 2016 | Nature genetics
Interdisciplinary approach towards a systems medicine toolbox using the example of inflammatory diseases.
PubMed (PMID: 27016392) | 2016 | Briefings in bioinformatics
Paternal chronic colitis causes epigenetic inheritance of susceptibility to colitis.
PubMed (PMID: 27538787) | 2016 | Scientific Reports
Vy-PER: eliminating false positive detection of virus integration events in next generation sequencing data.
PubMed (PMID: 26166306) | 2015 | Scientific Reports

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