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Institut für Klinische Molekularbiologie der Christian-Albrechts-Universität zu Kiel

Scientist

Michael Forster

Research Projects - Scientist

Childhood Leukemia Project

High Resolution 3D Stereo Light Microscopy

pibase tools for validational and comparative analysis of BAM files

Research Group

Genetics & Bioinformatics

Contact

+49 (0) 431 / 500 - 15 136

m.forster [at] ikmb.uni-kiel.de

Research Interest

Vision:
Molecular profiling to enable individualised curative therapy

Activity in Consortia:
READNA, ESGI, NGFN, UFO Sequencing Consortium within the ALL-BFM Study Group, e:Med SYSinflame.

Transatlantic collaborations with:
Avera Cancer Institute, JABSOM, Maikalani ATRC

Main Publications

Stage IV Colorectal Cancer Patients with High Risk Mutation Profiles Survived 16 Months Longer with Individualized Therapies.
PubMed (PMID: 32046290) | 2020 | Cancers
RNA based individualized drug selection in breast cancer patients without patient-matched normal tissue.
PubMed (PMID: 30190792) | 2018 | Oncotarget
Metastatic triple-negative breast cancer patient with TP53 tumor mutation experienced 11 months progression-free survival on bortezomib monotherapy without adverse events after ending standard treatments with grade 3 adverse events.
PubMed (PMID: 28679691) | 2017 | Cold Spring Harbor molecular case studies
Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.
PubMed (PMID: 26214592) | 2015 | Nature genetics
Rapid response of stage IV colorectal cancer with APC/TP53/KRAS mutations to FOLFIRI and Bevacizumab combination chemotherapy: a case report of use of liquid biopsy.
PubMed (PMID: 31900123) | 2020 | BMC medical genetics

Detection of Cancer Mutations by Urine Liquid Biopsy as a Potential Tool in the Clinical Management of Bladder Cancer Patients.
PubMed (PMID: 35205727) | 2022 | Cancers
High-throughput method for the hybridisation-based targeted enrichment of long genomic fragments for PacBio third-generation sequencing.
PubMed (PMID: 35855323) | 2022 | NAR Genomics and Bioinformatics
Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation.
PubMed (PMID: 34739342) | 2021 | Science immunology
Genetic Variation in ABCC4 and CFTR and Acute Pancreatitis during Treatment of Pediatric Acute Lymphoblastic Leukemia.
PubMed (PMID: 34768335) | 2021 | Journal of clinical medicine
Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease.
PubMed (PMID: 33888516) | 2021 | Gut : journal of the British Society of Gastroenterology
Liquid Biopsy in Gastric Cancer: Analysis of Somatic Cancer Tissue Mutations in Plasma Cell-Free DNA for Predicting Disease State and Patient Survival.
PubMed (PMID: 34644276) | 2021 | Clinical and translational gastroenterology
Quantifying sequencing error and effective sequencing depth of liquid biopsy NGS with UMI error correction.
PubMed (PMID: 33512245) | 2021 | BioTechniques the international journal of life science methods Protocol guide
Clinical responses to PD-1 inhibition and their molecular characterization in six patients with mismatch repair-deficient metastatic cancer of the digestive system.
PubMed (PMID: 32776177) | 2020 | Journal of cancer research and clinical oncology
Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19.
PubMed (PMID: 33296687) | 2020 | Immunity (Cambridge, Mass.)
Phylogenetic network analysis of SARS-CoV-2 genomes.
PubMed (PMID: 32269081) | 2020 | Proceedings of the National Academy of Sciences of the United States of America
Reply to Sánchez-Pacheco et al., Chookajorn, and Mavian et al.: Explaining phylogenetic network analysis of SARS-CoV-2 genomes.
PubMed (PMID: 32439706) | 2020 | Proceedings of the National Academy of Sciences of the United States of America
Two Prevalent ∼100-kb GYPB Deletions Causative of the GPB-Deficient Blood Group MNS Phenotype S-s-U- in Black Africans.
PubMed (PMID: 32884505) | 2020 | Transfusion medicine and hemotherapy
Effects of Quantification Methods, Isolation Kits, Plasma Biobanking, and Hemolysis on Cell-Free DNA Analysis in Plasma.
PubMed (PMID: 31343271) | 2019 | Biopreservation and biobanking
Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn's disease.
PubMed (PMID: 31822667) | 2019 | Nature communications
Missense variants in NOX1 and p22phox in a case of very-early-onset inflammatory bowel disease are functionally linked to NOD2.
PubMed (PMID: 30709874) | 2019 | Cold Spring Harbor molecular case studies
Grow With the Challenge - Microbial Effects on Epithelial Proliferation, Carcinogenesis, and Cancer Therapy.
PubMed (PMID: 30294304) | 2018 | Frontiers in Microbiology
NGS-based methylation profiling differentiates TCF3-HLF and TCF3-PBX1 positive B-cell acute lymphoblastic leukemia.
PubMed (PMID: 29334255) | 2018 | Epigenomics
Publisher Correction: Identification and characterization of two functional variants in the human longevity gene FOXO3.
PubMed (PMID: 29339726) | 2018 | Nature communications
Quantifying cell free DNA in urine: comparison between commercial kits, impact of gender and inter-individual variation.
PubMed (PMID: 29793362) | 2018 | BioTechniques the international journal of life science methods Protocol guide
Identification and characterization of two functional variants in the human longevity gene FOXO3.
PubMed (PMID: 29234056) | 2017 | Nature communications
Development of a high-resolution NGS-based HLA-typing and analysis pipeline.
PubMed (PMID: 25753671) | 2015 | Nucleic acids research
New technologies for DNA analysis - a review of the READNA Project.
PubMed (PMID: 26514324) | 2015 | New biotechnology
Vy-PER: eliminating false positive detection of virus integration events in next generation sequencing data.
PubMed (PMID: 26166306) | 2015 | Scientific Reports
Early-onset Crohn's disease and autoimmunity associated with a variant in CTLA-4.
PubMed (PMID: 25367873) | 2014 | Gut : journal of the British Society of Gastroenterology
Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies.
PubMed (PMID: 23624108) | 2013 | Gastroenterology (New York, N.Y. 1943)
From next-generation sequencing alignments to accurate comparison and validation of single-nucleotide variants: the pibase software.
PubMed (PMID: 22965131) | 2013 | Nucleic acids research
Accurate variant detection across non-amplified and whole genome amplified DNA using targeted next generation sequencing.
PubMed (PMID: 22994565) | 2012 | BMC genomics
Improving mapping and SNP-calling performance in multiplexed targeted next-generation sequencing.
PubMed (PMID: 22913592) | 2012 | BMC genomics
New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing.
PubMed (PMID: 22426219) | 2012 | Nature communications

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