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Institut für Klinische Molekularbiologie der Christian-Albrechts-Universität zu Kiel

Scientist

Michael Wittig

Research Projects - Scientist

CNV Typing

HLA Fine Mapping

HLA Typing

HLAssign

Research Group

Genetics & Bioinformatics

Contact

+49 (0) 431 / 500 - 15 166

m.wittig [at] mucosa.de

Research Interest

Main Publications

High-Resolution HLA-Typing by Next-Generation Sequencing of Randomly Fragmented Target DNA.
PubMed (PMID: 29858802) | 2018 | Methods in molecular biology (Clifton, N.J.)
Development of a high-resolution NGS-based HLA-typing and analysis pipeline.
PubMed (PMID: 25753671) | 2015 | Nucleic acids research
Maternal epigenetic pathways control parental contributions to Arabidopsis early embryogenesis.
PubMed (PMID: 21620136) | 2011 | Cell
Construction and benchmarking of a multi-ethnic reference panel for the imputation of HLA class I and II alleles.
PubMed (PMID: 30590525) | 2018 | Human molecular genetics
Interaction between mating-type proteins from the homothallic fungus Sordaria macrospora.
PubMed (PMID: 12111096) | 2002 | Current genetics

Complement Receptor 1 (CR1, CD35) Polymorphisms and Soluble CR1: A Proposed Anti-inflammatory Role to Quench the Fire of "Fogo Selvagem" Pemphigus Foliaceus.
PubMed (PMID: 31824479) | 2019 | Frontiers in immunology
Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans.
PubMed (PMID: 29717136) | 2018 | Nature communications
A post-GWAS analysis of predicted regulatory variants and tuberculosis susceptibility.
PubMed (PMID: 28384278) | 2017 | PloS one
A sex-chromosome inversion causes strong overdominance for sperm traits that affect siring success.
PubMed (PMID: 29046576) | 2017 | Nature ecology & evolution
Association mapping of morphological traits in wild and captive zebra finches: reliable within but not between populations.
PubMed (PMID: 28100011) | 2017 | Molecular ecology
HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry.
PubMed (PMID: 28695657) | 2017 | HLA
Fitness consequences of polymorphic inversions in the zebra finch genome.
PubMed (PMID: 27687629) | 2016 | Genome biology
Genome-wide rare copy number variation screening in ulcerative colitis identifies potential susceptibility loci.
PubMed (PMID: 27037036) | 2016 | BMC medical genetics
Acute physical exercise improves shifting in adolescents at school: evidence for a dopaminergic contribution.
PubMed (PMID: 26283937) | 2015 | Frontiers in behavioral neuroscience
Quantifying realized inbreeding in wild and captive animal populations.
PubMed (PMID: 25585923) | 2015 | Heredity : an international journal of genetics
16p11.2 600 kb Duplications confer risk for typical and atypical Rolandic epilepsy.
PubMed (PMID: 24939913) | 2014 | Human molecular genetics
The age related markers lipofuscin and apoptosis show different genetic architecture by QTL mapping in short-lived Nothobranchius fish.
PubMed (PMID: 25093339) | 2014 | Aging
From next-generation sequencing alignments to accurate comparison and validation of single-nucleotide variants: the pibase software.
PubMed (PMID: 22965131) | 2013 | Nucleic acids research
Genome-wide association analysis in Primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4.
PubMed (PMID: 22821403) | 2013 | Hepatology : official journal of the American Association for the Study of Liver Diseases
Genome-wide association analysis reveals 12q13.3-q14.1 as new risk locus for sarcoidosis.
PubMed (PMID: 22936702) | 2013 | The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology
A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals.
PubMed (PMID: 21740922) | 2011 | Mechanisms of ageing and development
A tissue-specific landscape of sense/antisense transcription in the mouse intestine.
PubMed (PMID: 21663663) | 2011 | BMC genomics
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
PubMed (PMID: 21833088) | 2011 | Nature : a weekly illustrated journal of science
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.
PubMed (PMID: 21151127) | 2011 | Nature genetics
A duplication in 1q21.3 in a family with early onset and childhood absence epilepsy.
PubMed (PMID: 21204805) | 2010 | Epilepsia (Copenhagen)
CNVineta: a data mining tool for large case-control copy number variation datasets.
PubMed (PMID: 20605930) | 2010 | Bioinformatics
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).
PubMed (PMID: 20228798) | 2010 | Nature genetics
Meta-analysis and imputation refines the association of 15q25 with smoking quantity.
PubMed (PMID: 20418889) | 2010 | Nature genetics
15q13.3 microdeletions increase risk of idiopathic generalized epilepsy.
PubMed (PMID: 19136953) | 2009 | Nature genetics
Familial and sporadic 15q13.3 microdeletions in idiopathic generalized epilepsy: precedent for disorders with complex inheritance.
PubMed (PMID: 19592580) | 2009 | Human molecular genetics
Systematic evaluation of the effect of common SNPs on pre-mRNA splicing.
PubMed (PMID: 19191320) | 2009 | Human mutation
Genome-wide association analysis in sarcoidosis and Crohn's disease unravels a common susceptibility locus on 10p12.2.
PubMed (PMID: 18723019) | 2008 | Gastroenterology (New York, N.Y. 1943)
A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease.
PubMed (PMID: 17632509) | 2007 | Nature genetics
Efficacy assessment of SNP sets for genome-wide disease association studies.
PubMed (PMID: 17726055) | 2007 | Nucleic acids research
Single base-pair substitutions in exon-intron junctions of human genes: nature, distribution, and consequences for mRNA splicing.
PubMed (PMID: 17001642) | 2007 | Human mutation
Systematic association mapping identifies NELL1 as a novel IBD disease gene.
PubMed (PMID: 17684544) | 2007 | PloS one
GENOMIZER: an integrated analysis system for genome-wide association data.
PubMed (PMID: 16652332) | 2006 | Human mutation

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