Institut für Klinische Molekularbiologie der Christian-Albrechts-Universität zu Kiel

Scientist / Junior Research Group / Schleswig-Holstein-Excellence-Chairs („SH Chairs“)

Petra Bacher

Research Projects - Scientist

Intestinal Immune Regulation

Research Group

Junior Research Groups

Contact

+49 (0) 431 / 500 - 31 005

p.bacher [at] ikmb.uni-kiel.de

Research Interest

Teaching Remit

You find more information on the teaching remit of Petra Bacher via CAU.

Main Publications

Antigen specificity and cross-reactivity drive functionally diverse anti-Aspergillus fumigatus T cell responses in cystic fibrosis.
PubMed (PMID: 36701198) | 2023 | The journal of clinical investigation
A novel unconventional T cell population enriched in Crohn's disease.
PubMed (PMID: 35264446) | 2022 | Gut : journal of the British Society of Gastroenterology
Low-Avidity CD4⁺ T Cell Responses to SARS-CoV-2 in Unexposed Individuals and Humans with Severe COVID-19.
PubMed (PMID: 33296686) | 2020 | Immunity (Cambridge, Mass.)
Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans.
PubMed (PMID: 30799037) | 2019 | Cell
Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans.
PubMed (PMID: 27773482) | 2016 | Cell

Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease.
PubMed (PMID: 36893735) | 2023 | Cell host & microbe
Challenges and opportunities in analyzing and modeling peptide presentation by HLA-II proteins.
PubMed (PMID: 37063883) | 2023 | Frontiers in immunology
Malassezia restricta promotes alcohol-induced liver injury.
PubMed (PMID: 36706195) | 2023 | Hepatology communications
Proliferative activity of antigen-specific CD154+ T cells against bacterial and fungal respiratory pathogens in cystic fibrosis decreases after initiation of highly effective CFTR modulator therapy.
PubMed (PMID: 37408761) | 2023 | Frontiers in pharmacology
Mycobacterium tuberculosis-specific CD4 T-cell scoring discriminates tuberculosis infection from disease.
PubMed (PMID: 35618277) | 2022 | The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology
A Notch/STAT3-driven Blimp-1/c-Maf-dependent molecular switch induces IL-10 expression in human CD4⁺ T cells and is defective in Crohn´s disease patients.
PubMed (PMID: 35169232) | 2022 | Mucosal immunology official journal of the Society for Mucosal Immunology
Detailed stratified GWAS analysis for severe COVID-19 in four European populations.
PubMed (PMID: 35848942) | 2022 | Human molecular genetics
Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies.
PubMed (PMID: 35684151) | 2022 | Nutrients
Efficacy, T cell activation and antibody responses in accelerated Plasmodium falciparum sporozoite chemoprophylaxis vaccine regimens.
PubMed (PMID: 35641527) | 2022 | NPJ vaccines
Resolving SARS-CoV-2 CD4⁺ T cell specificity via reverse epitope discovery.
PubMed (PMID: 35841887) | 2022 | Cell reports. Medicine
The long term vaccine-induced anti-SARS-CoV-2 immune response is impaired in quantity and quality under TNFα blockade.
PubMed (PMID: 35945627) | 2022 | Journal of medical virology
The pre-exposure SARS-CoV-2-specific T cell repertoire determines the quality of the immune response to vaccination.
PubMed (PMID: 35985324) | 2022 | Immunity (Cambridge, Mass.)
Adoptive Cell Transfer of Allogeneic Epstein-Barr Virus-Specific T Lymphocytes for Treatment of Refractory EBV-Associated Posttransplant Smooth Muscle Tumors: A Case Report.
PubMed (PMID: 34925312) | 2021 | Frontiers in immunology
Characterization of SARS-CoV-2 public CD4+ αβ T cell clonotypes through reverse epitope discovery.
PubMed (PMID: 34845450) | 2021 | Unknown Journal
Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients.
PubMed (PMID: 33622974) | 2021 | Science immunology
Decreased inflammatory cytokine production of antigen-specific CD4⁺ T cells in NMDA receptor encephalitis.
PubMed (PMID: 33442772) | 2021 | Journal of neurology
First manifestation of adult-onset Still's disease after COVID-19.
PubMed (PMID: 33817663) | 2021 | The Lancet. Rheumatology
Flow Cytometric Characterization of Human Antigen-Reactive T-Helper Cells.
PubMed (PMID: 33928550) | 2021 | Methods in molecular biology (Clifton, N.J.)
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).
PubMed (PMID: 34910301) | 2021 | European journal of immunology
Humoral protection to SARS-CoV2 declines faster in patients on TNF alpha blocking therapies.
PubMed (PMID: 34880128) | 2021 | RMD open
Immunopeptidomics toolkit library (IPTK): a python-based modular toolbox for analyzing immunopeptidomics data.
PubMed (PMID: 34404349) | 2021 | BMC bioinformatics
Rapid T cell receptor interaction grouping with ting.
PubMed (PMID: 33983394) | 2021 | Bioinformatics
Anti-fungal T cell responses in the lung and modulation by the gut-lung axis.
PubMed (PMID: 32679448) | 2020 | Current opinion in microbiology
Identification and characterization of antigen-specific CD4⁺ T cells targeting renally expressed antigens in human lupus nephritis with two independent methods.
PubMed (PMID: 33277543) | 2020 | Scientific Reports
Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19.
PubMed (PMID: 33296687) | 2020 | Immunity (Cambridge, Mass.)
Nuclear antigen-reactive CD4+ T cells expand in active systemic lupus erythematosus, produce effector cytokines, and invade the kidneys.
PubMed (PMID: 32592813) | 2020 | Kidney international
Primary and secondary anti-viral response captured by the dynamics and phenotype of individual T cell clones.
PubMed (PMID: 32081129) | 2020 | eLife
T cell immunity to commensal fungi.
PubMed (PMID: 33120172) | 2020 | Current opinion in microbiology
TCRs with segment TRAV9-2 or a CDR3 histidine are overrepresented among nickel-specific CD4+ T cells.
PubMed (PMID: 32298488) | 2020 | Allergy : European journal of allergy and clinical immunology : official journal of the European Academy of Allergology and Clinical Immunology
The domestic pig as human-relevant large animal model to study adaptive anti-fungal immune responses against airborne Aspergillus fumigatus.
PubMed (PMID: 32558930) | 2020 | European journal of immunology
The gut mycobiome: a novel player in chronic liver diseases.
PubMed (PMID: 33151407) | 2020 | Journal of gastroenterology / Japanese Society of Gastroenterology
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).
PubMed (PMID: 31633216) | 2019 | European journal of immunology
Mould-reactive T cells for the diagnosis of invasive mould infection-A prospective study.
PubMed (PMID: 31034691) | 2019 | Mycoses : diagnosis, therapy and prophylaxis of fungal diseases : official publ. d. Deutschsprachigen Mykologischen Gesellschaft e.V
Antigen-specific regulatory T-cell responses against aeroantigens and their role in allergy.
PubMed (PMID: 29858582) | 2018 | Mucosal immunology official journal of the Society for Mucosal Immunology
Candida-Reactive T Cells for the Diagnosis of Invasive Candida Infection-A Prospective Pilot Study.
PubMed (PMID: 29988394) | 2018 | Frontiers in Microbiology
CD137+CD154- Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures.
PubMed (PMID: 29467769) | 2018 | Frontiers in immunology
Fungus-Specific CD4 T Cells as Specific Sensors for Identification of Pulmonary Fungal Infections.
PubMed (PMID: 29168073) | 2018 | Mycopathologia / International Mycological Institute
Proteome Analysis Reveals the Conidial Surface Protein CcpA Essential for Virulence of the Pathogenic Fungus Aspergillus fumigatus.
PubMed (PMID: 30279286) | 2018 | mBio
The effect of regulatory T cells on tolerance to airborne allergens and allergen immunotherapy.
PubMed (PMID: 30527063) | 2018 | Journal of allergy and clinical immunology
[Gaps in the regulatory T cell shield generate immunopathologies].
PubMed (PMID: 30302535) | 2018 | Zeitschrift für Rheumatologie
Fecal Microbiota Transplantation, Commensal Escherichia coli and Lactobacillus johnsonii Strains Differentially Restore Intestinal and Systemic Adaptive Immune Cell Populations Following Broad-spectrum Antibiotic Treatment.
PubMed (PMID: 29321764) | 2017 | Frontiers in Microbiology
Guidelines for the use of flow cytometry and cell sorting in immunological studies.
PubMed (PMID: 29023707) | 2017 | European journal of immunology
Immune Responses to Broad-Spectrum Antibiotic Treatment and Fecal Microbiota Transplantation in Mice.
PubMed (PMID: 28469619) | 2017 | Frontiers in immunology
The Probiotic Compound VSL#3 Modulates Mucosal, Peripheral, and Systemic Immunity Following Murine Broad-Spectrum Antibiotic Treatment.
PubMed (PMID: 28529928) | 2017 | Frontiers in Cellular and Infection Microbiology
Immunoproteomics of Aspergillus for the development of biomarkers and immunotherapies.
PubMed (PMID: 27312145) | 2016 | Proteomics. Clinical applications
Clinical-scale isolation of the total Aspergillus fumigatus-reactive T-helper cell repertoire for adoptive transfer.
PubMed (PMID: 26188965) | 2015 | Cytotherapy
Fungus-specific CD4(+) T cells for rapid identification of invasive pulmonary mold infection.
PubMed (PMID: 25635493) | 2015 | American journal of respiratory and critical care medicine
New technologies for monitoring human antigen-specific T cells and regulatory T cells by flow-cytometry.
PubMed (PMID: 26004366) | 2015 | Current opinion in pharmacology
Antigen-specific expansion of human regulatory T cells as a major tolerance mechanism against mucosal fungi.
PubMed (PMID: 24301658) | 2014 | Mucosal immunology official journal of the Society for Mucosal Immunology
Identification of immunogenic antigens from Aspergillus fumigatus by direct multiparameter characterization of specific conventional and regulatory CD4+ T cells.
PubMed (PMID: 25172488) | 2014 | The journal of immunology
Antigen-reactive T cell enrichment for direct, high-resolution analysis of the human naive and memory Th cell repertoire.
PubMed (PMID: 23479226) | 2013 | The journal of immunology
Flow-cytometric analysis of rare antigen-specific T cells.
PubMed (PMID: 23788442) | 2013 | Cytometry. Part A : the journal of the International Society for Analytical Cytology
Substrate discrimination by ergothioneine transporter SLC22A4 and carnitine transporter SLC22A5: gain-of-function by interchange of selected amino acids.
PubMed (PMID: 19814996) | 2009 | Biochimica et biophysica acta

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Institute of Clinical
Molecular Biology
(IKMB)

IKMB

Petra Bacher

Research Projects - Scientist

Contact

Research Interest

Main Publications

Institute of Clinical Molecular Biology (IKMB)

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Petra Bacher

Research Projects - Scientist

Contact

Research Interest

Main Publications

Institute of Clinical
Molecular Biology
(IKMB)