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Institut für Klinische Molekularbiologie der Christian-Albrechts-Universität zu Kiel

Scientist

Sören Franzenburg

Research Projects - Scientist

Epigenome Analysis

MiRNA Sequencing

RRBS (Reduced Representation Bisulfite Sequencing)

Sequencing

Transcriptomics

Whole Exome Sequencing & Custom Enrichment

Whole Genome & De Novo Sequencing

Research Group

Genetics & Bioinformatics Systems Immunology

Contact

+49 (0) 431 / 500 - 15 160

s.franzenburg [at] ikmb.uni-kiel.de

Research Interest

Sören Franzenburg

Main Publications

MyD88-deficient Hydra reveal an ancient function of TLR signaling in sensing bacterial colonizers.
PubMed (PMID: 23112184) | 2012 | Proceedings of the National Academy of Sciences of the United States of America
Bacterial colonization of Hydra hatchlings follows a robust temporal pattern.
PubMed (PMID: 23344242) | 2013 | The ISME journal
Distinct antimicrobial peptide expression determines host species-specific bacterial associations.
PubMed (PMID: 24003149) | 2013 | Proceedings of the National Academy of Sciences of the United States of America
Bacteria-bacteria interactions within the microbiota of the ancestral metazoan Hydra contribute to fungal resistance.
PubMed (PMID: 25514534) | 2015 | The ISME journal
The Host as the Driver of the Microbiota in the Gut and External Environment of Drosophila melanogaster.
PubMed (PMID: 26150460) | 2015 | Applied and environmental microbiology

Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer's disease.
PubMed (PMID: 37149695) | 2023 | Alzheimer's research & therapy
Differential microRNA expression analyses across two brain regions in Alzheimer's disease.
PubMed (PMID: 36038535) | 2022 | Translational psychiatry
Epigenome-Wide Association Study in Peripheral Tissues Highlights DNA Methylation Profiles Associated with Episodic Memory Performance in Humans.
PubMed (PMID: 36359320) | 2022 | Biomedicines
Microbiota mediated plasticity promotes thermal adaptation in the sea anemone Nematostella vectensis.
PubMed (PMID: 35778405) | 2022 | Nature communications
The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2.
PubMed (PMID: 35063125) | 2022 | Stem cell reports
UBTF::ATXN7L3 gene fusion defines novel B cell precursor ALL subtype with CDX2 expression and need for intensified treatment.
PubMed (PMID: 35397658) | 2022 | Leukemia
Bottleneck size and selection level reproducibly impact evolution of antibiotic resistance.
PubMed (PMID: 34312522) | 2021 | Nature ecology & evolution
Deciphering a Marine Bone-Degrading Microbiome Reveals a Complex Community Effort.
PubMed (PMID: 33563781) | 2021 | mSystems
High potency of sequential therapy with only β-lactam antibiotics.
PubMed (PMID: 34318749) | 2021 | eLife
Individuality in the Immune Repertoire and Induced Response of the Sponge Halichondria panicea.
PubMed (PMID: 34220847) | 2021 | Frontiers in immunology
Methotrexate Treatment of Newly Diagnosed RA Patients Is Associated With DNA Methylation Differences at Genes Relevant for Disease Pathogenesis and Pharmacological Action.
PubMed (PMID: 34867944) | 2021 | Frontiers in immunology
MRI-Based Iron Phenotyping and Patient Selection for Next-Generation Sequencing of Non-Homeostatic Iron Regulator Hemochromatosis Genes.
PubMed (PMID: 34048062) | 2021 | Hepatology : official journal of the American Association for the Study of Liver Diseases
A Comprehensive Molecular Characterization of the Pancreatic Neuroendocrine Tumor Cell Lines BON-1 and QGP-1.
PubMed (PMID: 32183367) | 2020 | Cancers
Analysis of the brain transcriptome in lines of laying hens divergently selected for feather pecking.
PubMed (PMID: 32854615) | 2020 | BMC genomics
Bacteria- and temperature-regulated peptides modulate β-catenin signaling in Hydra.
PubMed (PMID: 32817436) | 2020 | Proceedings of the National Academy of Sciences of the United States of America
Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19.
PubMed (PMID: 33296687) | 2020 | Immunity (Cambridge, Mass.)
Microbial Strategies for Survival in the Glass Sponge Vazella pourtalesii.
PubMed (PMID: 32788407) | 2020 | mSystems
Pathogen-induced tissue-resident memory T_H17 (T_RM17) cells amplify autoimmune kidney disease.
PubMed (PMID: 32769171) | 2020 | Science immunology
Rheumatoid Arthritis Patients, Both Newly Diagnosed and Methotrexate Treated, Show More DNA Methylation Differences in CD4+ Memory Than in CD4+ Naïve T Cells.
PubMed (PMID: 32117312) | 2020 | Frontiers in immunology
Somatic genetic drift and multilevel selection in a clonal seagrass.
PubMed (PMID: 32393866) | 2020 | Nature ecology & evolution
Neutrality in the Metaorganism.
PubMed (PMID: 31216282) | 2019 | PLoS biology / Public Library of Science
Functional variation in the gut microbiome of wild Drosophila populations.
PubMed (PMID: 29802796) | 2018 | Molecular ecology
Neolithic and medieval virus genomes reveal complex evolution of hepatitis B
PubMed (PMID: 10) | 2018 | eLife
Neolithic and Medieval virus genomes reveal complex evolution of hepatitis B.
PubMed (PMID: 29745896) | 2018 | eLife
How gut transcriptional function of Drosophila melanogaster varies with the presence and composition of the gut microbiota.
PubMed (PMID: 29113026) | 2017 | Molecular ecology
Species-specific viromes in the ancestral holobiont Hydra.
PubMed (PMID: 25343582) | 2014 | PloS one
Where simplicity meets complexity: hydra, a model for host-microbe interactions.
PubMed (PMID: 22127887) | 2012 | Advances in experimental medicine and biology

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